乳酸化修饰在年龄相关性疾病中的研究新进展

LactylationKlais a novel mechanism of protein post-translational modificationwhich is formed by covalent coupling of lactate produced by glycolysis with lysine residuesmainly including histone lactylation and non-histone lactylationAt presentthe study found that the main through regulating gene transcription and protein expression and subcellular localization to participate in the process of life activity in the cell. With the increase of agelactate metabolism in multiple organs of the body is disorderedand recent studies have found that lactylation mediated by it can participate in the occurrence and development of a variety of age-related diseases. Thereforethis paper aims to review the functional and mechanistic studies of lactylation in age-related diseases.