Clonally heritable gene expression imparts a layer of diversity within cell types
Clonally heritable gene expression imparts a layer of diversity within cell types
Abstract Cell types can be classified based on shared patterns of transcription. Variability in gene expression between individual cells of the same type has been ascribed to stochastic transcriptional bursting and transient cell states. We asked whether long-term, heritable differences in transcription can impart diversity within a cell type. Studying clonal human lymphocytes and mouse brain cells, we uncover a vast diversity of heritable transcriptional states among different clones of cells of the same type in vivo. In lymphocytes we show that this diversity is coupled to clone specific chromatin accessibility, resulting in distinct expression of genes by different clones. Our findings identify a source of cellular diversity, which may have important implications for how cellular populations are shaped by selective processes in development, aging and disease.
Berghenstr?hle Joseph、Ratz Michael、Eriksson Carl-Johan、Blom Kim、Fris¨|n Jonas、Mold Jeff E.、Weissman Martin H.、Martin Marcel、Lagergren Jens、Hagemann-Jensen Michael、Lundeberg Joakim、von Berlin Leonie、H?rd Joanna、Toosi Hosein、Sandberg Rickard、Micha?lsson Jakob
SciLifeLab, Department of Gene Technology, KTH Royal Institute of TechnologyDepartment of Cell and Molecular Biology, Karolinska InstituteDepartment of Cell and Molecular Biology, Karolinska InstituteCenter for Infectious Medicine, Department of Medicine HuddingeDepartment of Cell and Molecular Biology, Karolinska InstituteDepartment of Cell and Molecular Biology, Karolinska InstituteMathematics Department, University of CaliforniaDepartment of Biochemistry and Biophysics, National Bioinformatics Infrastructure SwedenSciLifeLab, Computational Science and Technology department, KTH Royal Institute of TechnologyDepartment of Cell and Molecular Biology, Karolinska InstituteSciLifeLab, Department of Gene Technology, KTH Royal Institute of TechnologyDepartment of Cell and Molecular Biology, Karolinska InstituteDepartment of Cell and Molecular Biology, Karolinska InstituteSciLifeLab, Computational Science and Technology department, KTH Royal Institute of TechnologyDepartment of Cell and Molecular Biology, Karolinska InstituteCenter for Infectious Medicine, Department of Medicine Huddinge
细胞生物学遗传学分子生物学
Berghenstr?hle Joseph,Ratz Michael,Eriksson Carl-Johan,Blom Kim,Fris¨|n Jonas,Mold Jeff E.,Weissman Martin H.,Martin Marcel,Lagergren Jens,Hagemann-Jensen Michael,Lundeberg Joakim,von Berlin Leonie,H?rd Joanna,Toosi Hosein,Sandberg Rickard,Micha?lsson Jakob.Clonally heritable gene expression imparts a layer of diversity within cell types[EB/OL].(2025-03-28)[2025-06-16].https://www.biorxiv.org/content/10.1101/2022.02.14.480352.点此复制
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