免疫检查点抑制剂相关不良反应：临床表现与发生机制
dverse events associated with immune checkpoint inhibitors: clinical manifestations and mechanisms
免疫检查点抑制剂通过靶向调节并激活患者自身的T淋巴细胞以对抗肿瘤，已在许多恶性肿瘤中取得显著疗效。然而，这种激活也可能失控攻击身体的正常组织和器官，导致不同程度的免疫相关疾病和其他并发症，即免疫相关不良反应。本文旨在探讨免疫检查点抑制剂相关不良反应的临床表现与发生机制。
Immune checkpoint inhibitors have demonstrated significant efficacy in various malignant tumors by selectively activating the patients own T lymphocytes against cancer cells. However, this activation can also lead to uncontrolled attacks on normal tissues and organs, resulting in immune-related adverse events of varying severity. This article aims to investigate the clinical manifestations and underlying mechanisms of these immune-related adverse reactions.
陈海峰、钱韵
肿瘤学临床医学基础医学药学
免疫相关不良事件免疫检查点抑制剂肿瘤免疫治疗
Immune-related adverse eventsImmune checkpoint inhibitorsumorsImmunotherapy
陈海峰,钱韵.免疫检查点抑制剂相关不良反应：临床表现与发生机制[EB/OL].(2025-01-08)[2025-07-20].https://www.biomedrxiv.org.cn/article/doi/bmr.202502.00010.点此复制
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