海藻酸微球-多孔钛复合药物投递涂层

his study reports a composite drug-elution coating for bone implants. Porous titanium coating was fabricated by replication of polyurethane foam and vacuum sintering. Vancomycin-loaded alginate microspheres were prepared by a emulsion method and free-dried into powders. Dry microsphere powders were dispensed into the porous titanium coating and hydrated using a small amount of water. The microspheres agglomoerated into hundred micron-sized clusters and became entrapped-immobilized in the pores, thus forming a composite drug-elution coating. Release fluid was collected from the coating and used to test in vitro antibacterial activities against S. aureus. The fluid collected on day 4 produced a clear inhibition zone, indicating its antibacterial activity. These results may provide a general coating design for implant-based releae of drugs.