系统性硬化症合并干燥综合征的临床和实验室特点分析及危险因素研究

Background &nbsp;Systemic sclerosiSScis a heterogeneous diseaseoften accompanied by Sjgren's syndromeSS. Some symptoms of SSc patients are similar to SSand SS is easily missed in the clinical diagnosis and treatment.Objective &nbsp;To explore the clinical and laboratory characteristics of SSc combined with SS and the risk factors of overlapping incidence. Methods &nbsp;A retrospective study was conducted on SSc patients hospitalized and treated at the Ningbo Medical Center Lihuili Hospital from 2019 to 2023. Baseline data and laboratory test results of the patients were collected. Patients were divided into two groups based on the presence or absence of SS: the SSc groupn=91and the SSc with SS groupn=36. Multifactorial Logistic regression analysis was used to explore the risk factors for SSc with SS. Results &nbsp;The proportion of female patients disease durationblood involvementlimited cutaneous systemic sclerosislcSScand the proportion of autoimmune liver disease in the SSc with SS group were higher than in the SSc groupwhile the proportion of lung involvement and the use of cyclophosphamide were lowerP<0.05. The SSc with SS group had lower platelet distribution widthcomplement C4and anti-Scl-70 antibody detection rates compared to the SSc groupwhile the detection rates of alkaline phosphataseglutamyl transpeptidaseimmunoglobulin MIgManti-centromere protein B antibodiesanti-CENP-B antibodiesanti#2;Sjgren's syndrome A/Ro52 antibodiesanti-SSA/Ro52 antibodiesanti-Sjgren's syndrome A/Ro60 antibodiesanti-SSA/ Ro60 antibodiesanti-Sjgren's syndrome B antibodiesanti-SSB antibodiesand anti-mitochondrial M2 antibodies anti-AMA-M2 antibodieswere higher in the SSc with SS group. Multifactorial Logistic regression analysis showed that elevated IgMOR=3.79695%CI=1.021-14.115positive anti-SSA/Ro52 antibodiesOR=15.09995%CI=1.750- 130.264and positive anti-CENP-B antibodiesOR=11.68195%CI=1.662-82.097are independent risk factors for SSc with SSP<0.05. Conclusion &nbsp;The SSc combined with SS patients have the characteristics of both. When SSc patients have high IgMpositive anti-SSA and anti-CENP-B antibodies and corresponding clinical symptomssystematic and comprehensive examinations such as labial gland biopsy should be performed to prevent missed diagnosis.