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腹膜透析相关性腹膜炎检验流程证据总结与单中心优化经验

Peritoneal Dialysis-Associated Peritonitis:Existing Evidence Summary and Single-center Experience of Optimization of Testing Procedure

中文摘要英文摘要

腹膜透析相关性腹膜炎(PDAP)是导致腹膜透析技术失败甚至患者死亡的首要并发症,尽早获得准确有效的病原学鉴定结果指导抗感染方案是影响PDAP临床疗效的关键环节。本文系统回顾了广东省中医院腹透中心PDAP病原微生物检测方法及现状,在梳理国际临床实践指南和标准操作规程等临床证据的基础上,从“标本留取”“标本预处理”“培养条件”及“首次培养阴性处理”四个方面归纳总结了影响PDAP培养阳性率的技术要点和潜在改进措施;并以省中医腹透中心为示例,展示了如何结合现有临床证据,从患者宣教、多学科协作、标本处理等方面对单中心的PDAP标本处理及送检流程进行完善及优化,提供可行的单中心经验,供国内其他腹膜透析中心参考。

Peritoneal dialysis-associated peritonitisPDAPis a major complication that can lead to peritoneal dialysis failure and increased mortality. Accurate and timely identification of the causative pathogens is essential for effective treatment of PDAP. This article systematically reviewed the methods and practices for PDAP pathogen detection at the Peritoneal Dialysis Center of Guangdong Provincial Hospital of Chinese Medicine and summarized current best evidence and the technical points that were potentially affecting the culture-positive rate of PDAPfocusing on specimen collectionpre-treatmentcultivationand follow-up of initially negative cultures. By using this center as a case studythe article demonstrates how to integrate clinical evidence with practice to optimize PDAP pathogens identification and highlights key technical aspectssuch as patient education and multidisciplinary collaborationthat influence culture-positive rates. The findings offer a practical model for other centers in China.

钟静怡、程招敏、伍剑锋、谢小宁、彭钰、张腊、卢富华、胡晓璇

医药卫生

腹膜透析腹膜透析相关性腹膜炎培养技术检测技术证据总结

钟静怡,程招敏,伍剑锋,谢小宁,彭钰,张腊,卢富华,胡晓璇.腹膜透析相关性腹膜炎检验流程证据总结与单中心优化经验[EB/OL].(2024-11-19)[2024-11-21].https://chinaxiv.org/abs/202411.00204.点此复制

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