2024 年《NCCN 胃癌临床实践指南》更新要点解读

In 2024the National Comprehensive Cancer NetworkNCCNhas updated three editions of the Clinical Practice Guidelines for Gastric Cancer. These updates encompass multiple crucial areas of diagnosistreatmentand follow-up monitoring for gastric cancer. It elevates the significance of next-generation sequencing in precision therapy for gastric cancerrefines the limitations for Epstein-Barr virusEBVtesting and first-line immunotherapy in advanced stages. Adjustments have been made to the preoperative medication cycle for neoadjuvant immunotherapya new NTRK-targeted therapy drug was added in the second-line therapyand a more detailed approach to postoperative monitoring and supplementation for nutritional deficiencies has been introduced. Notablythis version marks the first inclusion of endoscopic treatment pathways for early-stage gastric cancer and diagnostic and treatment pathways for single peritoneal metastasis in advanced gastric cancer. Additionallyit provides a comprehensive elaboration on the application principles of several emerging surgical techniques combined with intraperitoneal treatments. The updated content fully embodies the trend towards precisionpersonalizedand multidisciplinary treatment. This article will focus on the diagnosissurgical treatmentsystemic treatmentfollow-up monitoring and other aspects of the guidelinein order to provide guidance and help for clinical practice.