生物节律调控脂滴代谢影响果蝇抗氧化应激能力

he physiological and behavioral activities of most organisms on Earth exhibit a circadian rhythm of approximately 24 hours, driven by a core feedback loop regulated by post-transcriptional and translational modifications. In animals, circadian rhythms regulate various metabolic pathways, including lipid metabolism. In this study, we found significant diurnal variations in lipid droplets within the brain tissue of Drosophila. Downregulation of the lipid droplet-related gene Lsd in the circadian neurons of Drosophila led to a decrease in lipid droplet quantity and a reduction in oxidative stress resistance. In summary, our findings suggest that circadian neurons influence oxidative stress resistance in Drosophila by regulating lipid droplet metabolism.