模型引导的移植患者他克莫司精准用药专家共识

There is significant inter-individual variation of pharmacokinetics and pharmacodynamics in patients receiving therapy of tacrolimus（TAC） after transplantation, which cause the rejection or toxic action. Through modeling and simulation based on results of therapeutic drug monitoring and pathophysiological index of transplant patients, the individualized therapeutic regimen can be designed and adjusted. Thus, the target of rational drug using can be obtained. In the consensus, the different methods of model induced precise dosing used for patients received TAC after transplantation were introduced, which can be used for the designing and adjusting doing regimen, predicting adverse drug reaction, improving medication adherence and economics after transplantation.