外泌体微小 RNA 参与糖尿病足溃疡修复的研究进展

iabetic foot ulcerDFUis usually accompanied by varying degrees of peripheral neuropathy and vasculopathy. It is a difficult-to-heal wound. The delayed healing process is mainly due to new blood vessel regeneration disorderpersistent wound inflammationwound re-epithelialization disorder and abnormal fibroblast proliferation. Exosomal miRNAas an important medium for intercellular communicationis involved in a variety of biological processes and can regulate the transcription and translation of various target genes affecting DFU healing. This paper aims to briefly review the role of exosomal miRNAs in the regulation of neointimal regenerationinflammatory responsewound re-epithelialization functionand fibroblast proliferation function in the repair of DFUto provide new ideas for the treatment of DFU.