清醒静息过程的记忆巩固：基于脑电和功能磁共振的研究

Both wakeful rest and sleep are beneficial for offline memory consolidation. However, our understanding of the connections and differences in memory consolidation between these two states, especially regarding the shared cognitive neural mechanisms, remains limited. This study adopts cutting-edge technologies, such as EEG, fMRI, temporal interference electrical stimulation, and computational neuroscience techniques, to carry out the following works. First, through joint neuroimaging experiments of waking rest and sleep, the neural activities of memory consolidation are compared between the two states to reveal the essential characteristics of offline memory consolidation. Second, establish a closed-loop stimulation system based on neural replay to investigate the neural characteristics of offline memory consolidation from a causal perspective. Third, conduct real-time neural feedback-based hippocampal electrical stimulation research to develop a protocol for regulating memory consolidation. This study holds profound theoretical significance for elucidating the neural mechanisms of offline memory consolidation and provides scientific evidence for the regulation of memory consolidation in the waking state in the future.