心脏巨噬细胞在射血分数保留性心力衰竭中的研究进展

Heart failure with preserved ejection fractionHFpEFis a universal and highly fatal global diseaseaccounting for nearly 50% of patients with heart failure. Innovative methods are needed to protect cardiac function and prevent the progression of HFpEF. Cardiac macrophagesCMshave emerged as key regulators of the pathophysiology of HFpEF. CMs are a heterogeneous population consisting of subpopulations with distinct lineage origins and gene expression profiles. Several key aspects of HFpEF progression have been shown to be regulated by CMsincluding the recruitment of peripheral immune cellsmyocardial inflammationand cardiac electrical conduction. In additionCMs play a critical role in regulating cardiac fibrosisepicardial adipose tissue dysfunctionand ventricular diastolic dysfunction. Given the multifaceted roles of CMs in the pathophysiology of HFpEFtargeted regulation of CMs represents a promising therapeutic strategy. Thereforethis article will review the research progress between CMs and the pathophysiological mechanism of HFpEF from the aspects of cardiac inflammation and fibrosisventricular diastolic dysfunctionepicardial adipose tissuecardiac electrical conductionand clinical intervention.