Codiversification of gut microbiota with humans
Codiversification of gut microbiota with humans
Abstract Some gut microbes have cospeciated with hominids, but whether they further codiversified with human populations is unclear. Here, we identify predominant gut microbial species sharing a parallel evolutionary history with human populations. Patterns of strain transfer between populations are generally consistent with an African origin, and suggest long-term vertical transmission over thousands of generations. We show the same strains also faithfully transmit between mothers and their children. Consistent with the development of intimate symbiosis, species with strongest patterns of codiversification have the smallest genomes. This study reveals long-term fidelity of gut microbiota with human populations through transmission among individuals living in close proximity. Dominance of specific strains in different populations is based in part on vertical transmission and they may provide population-specific health benefits. One-sentence summaryIdentification of gut microbes that codiversified with human populations.
Kremsner Peter、Ley Ruth E.、Schmidt Victor T.、Huus Kelsey、Adegbite Bayode R.、Velavan Thirumalaisamy P.、Spector Timothy D.、Blekhman Ran、S¨|gurel Laure、Suzuki Taichi A.、Fitzstevens Liam、Esen Meral、Adegnika Ayola A.、Enav Hagay、Zinsou Jeannot F.、Marchi Nina、Mbong Mirabeau、Muehlbauer Amanda L.、Youngblut Nicholas D.、Song Le Huu
University of T¨1bingen, Institute for Tropical Medicine||Centre de Recherches M¨|dicales de Lambar¨|n¨|||German Center for Infection Research (DZIF)||Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of T¨1bingen||Vietnamese German Center for Medical Research (VG-CARE)Max Planck Institute for Developmental Biology, Department of Microbiome Sciences||Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of T¨1bingenMax Planck Institute for Developmental Biology, Department of Microbiome SciencesMax Planck Institute for Developmental Biology, Department of Microbiome SciencesUniversity of T¨1bingen, Institute for Tropical Medicine||Centre de Recherches M¨|dicales de Lambar¨|n¨|University of T¨1bingen, Institute for Tropical Medicine||Vietnamese German Center for Medical Research (VG-CARE)Department of Twin Research & Genetic Epidemiology, King?ˉs College LondonDepartment of Genetics, Cell Biology, and Development, University of MinnesotaEco-anthropologie, Mus¨|um National d?ˉHistoire Naturelle¨CCNRS¨CUniversit¨| de Paris||Laboratoire de Biom¨|trie et Biologie Evolutive, CNRS - Universit¨| Lyon 1Max Planck Institute for Developmental Biology, Department of Microbiome SciencesMax Planck Institute for Developmental Biology, Department of Microbiome SciencesUniversity of T¨1bingen, Institute for Tropical Medicine||German Center for Infection Research (DZIF)||Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of T¨1bingenUniversity of T¨1bingen, Institute for Tropical Medicine||Centre de Recherches M¨|dicales de Lambar¨|n¨|||German Center for Infection Research (DZIF)||Fondation pour la Recherche ScientifiqueMax Planck Institute for Developmental Biology, Department of Microbiome SciencesUniversity of T¨1bingen, Institute for Tropical Medicine||Centre de Recherches M¨|dicales de Lambar¨|n¨|Eco-anthropologie, Mus¨|um National d?ˉHistoire Naturelle¨CCNRS¨CUniversit¨| de ParisMax Planck Institute for Developmental Biology, Department of Microbiome SciencesDepartment of Ecology, Evolution, and Behavior, University of MinnesotaMax Planck Institute for Developmental Biology, Department of Microbiome SciencesVietnamese German Center for Medical Research (VG-CARE)||108 Military Central Hospital
微生物学人类学分子生物学
Kremsner Peter,Ley Ruth E.,Schmidt Victor T.,Huus Kelsey,Adegbite Bayode R.,Velavan Thirumalaisamy P.,Spector Timothy D.,Blekhman Ran,S¨|gurel Laure,Suzuki Taichi A.,Fitzstevens Liam,Esen Meral,Adegnika Ayola A.,Enav Hagay,Zinsou Jeannot F.,Marchi Nina,Mbong Mirabeau,Muehlbauer Amanda L.,Youngblut Nicholas D.,Song Le Huu.Codiversification of gut microbiota with humans[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2021.10.12.462973.点此复制
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