Inference and reconstruction of the heimdallarchaeial ancestry of eukaryotes
Inference and reconstruction of the heimdallarchaeial ancestry of eukaryotes
Abstract In the ongoing debates about eukaryogenesis, the series of evolutionary events leading to the emergence of the eukaryotic cell from prokaryotic ancestors, members of the Asgard archaea play a key role as the closest archaeal relatives of eukaryotes. However, the nature and phylogenetic identity of the last common ancestor of Asgard archaea and eukaryotes remain unresolved. Here, we analyze distinct phylogenetic marker datasets of an expanded genomic sampling of Asgard archaea and evaluate competing evolutionary scenarios using state-of-the-art phylogenomic approaches. We find that eukaryotes are placed, with high confidence, as a well-nested clade within Asgard archaea, as a sister lineage to Hodarchaeales, a newly proposed order within Heimdallarchaeia. Using sophisticated gene tree/species tree reconciliation approaches, we show that, in analogy to the evolution of eukaryotic genomes, genome evolution in Asgard archaea involved significantly more gene duplication and fewer gene loss events compared to other archaea. Finally, we infer that the last common ancestor of Asgard archaea likely was a thermophilic chemolithotroph, and that the lineage from which eukaryotes evolved adapted to mesophilic conditions and acquired the genetic potential to support a heterotrophic lifestyle. Our work provides key insights into the prokaryote-to-eukaryote transition and the platform for the emergence of cellular complexity in eukaryotic cells.
Saw Jimmy H.、John Emily St、Eme Laura、Tamarit Daniel、Caceres Eva F.、Sch?n Max E.、Seitz Kiley W.、Homa Felix、Lombard Jonathan、Reysenbach Anna-Louise、Kjeldsen Kasper U.、Ettema Thijs J. G.、Baker Brett J.、Chen Lin-Xing、Hua Zheng-Shuang、Schramm Andreas、Stott Matthew B.、Stairs Courtney W.、Banfield Jillian F.、Teske Andreas P.、Nunoura Takuro、Dombrowski Nina、Li Wen-Jun、Anda Valerie De、Lewis William H.
Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala UniversityDepartment of Biology, Portland State UniversityDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University||Laboratoire ¨|cologieDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University||Laboratoire ¨|cologie||Laboratory of Microbiology, Wageningen University and ResearchDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University||Laboratory of Microbiology, Wageningen University and ResearchDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala UniversityDepartment of Marine Science, Marine Science Institute, University of Texas AustinLaboratory of Microbiology, Wageningen University and ResearchDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala UniversityDepartment of Biology, Portland State Universityof Biology, Aarhus UniversityDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University||Laboratory of Microbiology, Wageningen University and ResearchDepartment of Marine Science, Marine Science Institute, University of Texas Austin||Department of Integrative Biology, University of Texas AustinDepartment of Earth and Planetary Sciences, University of CaliforniaChinese Academy of Sciences Key Laboratory of Urban Pollutant Conversion, Department of Environmental Science and Engineering, University of Science and Technology of Chinaof Biology, Aarhus UniversitySchool of Biological Sciences, University of CanterburyDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala UniversityDepartment of Earth and Planetary Sciences, University of California||Department of Environmental Science University of CaliforniaDepartment of Earth, Marine and Environmental Sciences, University of North CarolinaResearch Center for Bioscience and Nanoscience (CeBN), Japan Agency for Marine-Earth Science and Technology (JAMSTEC)Department of Marine Science, Marine Science Institute, University of Texas AustinState Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen UniversityDepartment of Marine Science, Marine Science Institute, University of Texas AustinDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University||Laboratory of Microbiology, Wageningen University and Research
细胞生物学分子生物学微生物学
Saw Jimmy H.,John Emily St,Eme Laura,Tamarit Daniel,Caceres Eva F.,Sch?n Max E.,Seitz Kiley W.,Homa Felix,Lombard Jonathan,Reysenbach Anna-Louise,Kjeldsen Kasper U.,Ettema Thijs J. G.,Baker Brett J.,Chen Lin-Xing,Hua Zheng-Shuang,Schramm Andreas,Stott Matthew B.,Stairs Courtney W.,Banfield Jillian F.,Teske Andreas P.,Nunoura Takuro,Dombrowski Nina,Li Wen-Jun,Anda Valerie De,Lewis William H..Inference and reconstruction of the heimdallarchaeial ancestry of eukaryotes[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/2023.03.07.531504.点此复制
评论