Shared genetic influences on resting-state functional networks of the brain
Shared genetic influences on resting-state functional networks of the brain
Abstract The amplitude of activation in brain resting state networks (RSNs), measured with resting-state functional MRI, is heritable and genetically correlated across RSNs, indicating pleiotropy. Recent univariate genome-wide association studies (GWAS) explored the genetic underpinnings of RSNs, but do not describe their pleiotropic nature. In this study, we used multivariate genomic structural equation modelling to model latent factors that capture shared genomic influences. Using summary statistics from GWAS of 21 RSNs in the UK Biobank (N = 21,081) sample, we show that their genetic organization can be best explained by two distinct but correlated genetic factors that divide multimodal association networks and sensory networks. We identify single-nucleotide polymorphisms and genes associated with the joint architecture of resting-state networks. We conclude that multivariate models of genetic structures can help us to learn more about the biological mechanisms involved in brain function.
Franke B、Beckmann CF、Guimaraes JPOFT、Sprooten E、Bralten J
Donders Institute for Brain, Cognition and Behaviour, Radboud University||Department of Human Genetics, Radboud University Medical Center||Department of Psychiatry, Radboud University Medical CenterDepartment of Cognitive Neuroscience, Radboud University Medical Center||Donders Institute for Brain, Cognition and Behaviour, Radboud University||Centre for Functional MRI of the Brain (FMRIB), University of OxfordDepartment of Cognitive Neuroscience, Radboud University Medical Center||Donders Institute for Brain, Cognition and Behaviour, Radboud University||Department of Human Genetics, Radboud University Medical CenterDepartment of Cognitive Neuroscience, Radboud University Medical Center||Donders Institute for Brain, Cognition and Behaviour, Radboud University||Department of Human Genetics, Radboud University Medical CenterDonders Institute for Brain, Cognition and Behaviour, Radboud University||Department of Human Genetics, Radboud University Medical Center
基础医学生物科学研究方法、生物科学研究技术神经病学、精神病学
Franke B,Beckmann CF,Guimaraes JPOFT,Sprooten E,Bralten J.Shared genetic influences on resting-state functional networks of the brain[EB/OL].(2025-03-28)[2025-05-09].https://www.biorxiv.org/content/10.1101/2021.02.15.431231.点此复制
评论