Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC
Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC
Abstract Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as treatment for Coronavirus Disease 2019 (COVID-19). We compared the mortality and clinical outcome of patients with COVID-19 who received 200mL of CCP with a Spike protein IgG titer ≥1:2,430 (median 1:47,385) within 72 hours of admission to propensity score-matched controls cared for at a medical center in the Bronx, between April 13 to May 4, 2020. Matching criteria for controls were age, sex, body mass index, race, ethnicity, comorbidities, week of admission, oxygen requirement, D-dimer, lymphocyte counts, corticosteroids, and anticoagulation use. There was no difference in mortality or oxygenation between CCP recipients and controls at day 28. When stratified by age, compared to matched controls, CCP recipients <65 years had 4-fold lower mortality and 4-fold lower deterioration in oxygenation or mortality at day 28. For CCP recipients, pre-transfusion Spike protein IgG, IgM and IgA titers were associated with mortality at day 28 in univariate analyses. No adverse effects of CCP were observed. Our results suggest CCP may be beneficial for hospitalized patients <65 years, but data from controlled trials is needed to validate this finding and establish the effect of ageing on CCP efficacy.
Barboto Daniel、Bartash Rachel、Chandran Kartik、Rivera Johanna、Khokhar Ahmed、Lee Audrey、Malaviya Avinash、Uehlinger Joan、Lai Jonathan R.、Fox Amy S.、Wang Tao、Gendlina Inessa、Bortz Robert H. III、Wirchnianski Ariel S.、Paroder Monika、Florez Catalina、Jangra Rohit K.、Tong Karen、Mariano Margarette C.、Georgiev George I.、Herrera Natalia G.、Malonis Ryan J.、Sweeney Joseph M.、Cowman Kelsie、Li Yang、Sarwar Uzma N.、Vergnolle Olivia、Garforth Scott J.、Pirofski Liise-anne、Barnhill Jason、Applebaum Ariella、Fehn Karen、Krause Gregory J.、Fels J. Maximilian、Babb Rachelle、Daily Johanna P.、Yang Xiuyi A.、Quiroz Jose A.、Goldstein Doctor Y.、Gil Morayma Reyes、Allen Stephanie、Haslwanter Denise、Annam Jayabhargav、Yoon Hyun ah、Sample Reise、Thota Raja、Dieterle M. Eugenia、Serrano-Rahman Leana、Lally Brianna J.、Almo Steven C.、Laudermilch Ethan、Morano Nicholas C.、Ruiz Rafael、Nakouzi Antonio、Lee Max
Albert Einstein College of MedicineDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Microbiology and Immunology. Albert Einstein College of MedicineDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical Center||Department of Microbiology and Immunology. Albert Einstein College of MedicineAlbert Einstein College of MedicineAlbert Einstein College of MedicineAlbert Einstein College of MedicineDepartment of Pathology. Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Biochemistry. Albert Einstein College of MedicineDepartment of Pathology. Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Epidemiology and Population Health. Albert Einstein College of MedicineDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Microbiology and Immunology. Albert Einstein College of MedicineDepartment of Microbiology and Immunology. Albert Einstein College of Medicine||Department of Biochemistry. Albert Einstein College of MedicineDepartment of Pathology. Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Microbiology and Immunology. Albert Einstein College of Medicine||Department of Chemistry and Life Science, United States Military Academy at West PointDepartment of Microbiology and Immunology. Albert Einstein College of MedicineDepartment of Biochemistry. Albert Einstein College of MedicineDepartment of Biochemistry. Albert Einstein College of MedicineDepartment of Biochemistry. Albert Einstein College of MedicineDepartment of Biochemistry. Albert Einstein College of MedicineDepartment of Biochemistry. Albert Einstein College of MedicineDepartment Physiology and Biophysics. Albert Einstein College of MedicineDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Epidemiology and Population Health. Albert Einstein College of MedicineDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Biochemistry. Albert Einstein College of MedicineDepartment of Biochemistry. Albert Einstein College of MedicineDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical Center||Department of Microbiology and Immunology. Albert Einstein College of MedicineDepartment of Chemistry and Life Science, United States Military Academy at West PointAlbert Einstein College of MedicineDepartment of Oncology. Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Developmental and Molecular Biology. Albert Einstein College of Medicine||Institute of Aging Studies. Albert Einstein College of MedicineDepartment of Microbiology and Immunology. Albert Einstein College of MedicineDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical Center||Department of Microbiology and Immunology. Albert Einstein College of MedicineDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical Center||Department of Microbiology and Immunology. Albert Einstein College of MedicineAlbert Einstein College of MedicineDepartment of Biochemistry. Albert Einstein College of MedicineDepartment of Pathology. Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Pathology. Albert Einstein College of Medicine and Montefiore Medical CenterAlbert Einstein College of MedicineDepartment of Microbiology and Immunology. Albert Einstein College of MedicineAlbert Einstein College of MedicineDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical CenterAlbert Einstein College of MedicineNetwork Performance Group. Montefiore Medical CenterDepartment of Microbiology and Immunology. Albert Einstein College of MedicineDepartment of Pathology. Albert Einstein College of Medicine and Montefiore Medical CenterAlbert Einstein College of MedicineDepartment of Biochemistry. Albert Einstein College of Medicine||Department Physiology and Biophysics. Albert Einstein College of MedicineDepartment of Microbiology and Immunology. Albert Einstein College of MedicineDepartment of Biochemistry. Albert Einstein College of MedicineNetwork Performance Group. Montefiore Medical Center||Division of Hospital Medicine, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical CenterDivision of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical Center||Department of Microbiology and Immunology. Albert Einstein College of MedicineAlbert Einstein College of Medicine
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Barboto Daniel,Bartash Rachel,Chandran Kartik,Rivera Johanna,Khokhar Ahmed,Lee Audrey,Malaviya Avinash,Uehlinger Joan,Lai Jonathan R.,Fox Amy S.,Wang Tao,Gendlina Inessa,Bortz Robert H. III,Wirchnianski Ariel S.,Paroder Monika,Florez Catalina,Jangra Rohit K.,Tong Karen,Mariano Margarette C.,Georgiev George I.,Herrera Natalia G.,Malonis Ryan J.,Sweeney Joseph M.,Cowman Kelsie,Li Yang,Sarwar Uzma N.,Vergnolle Olivia,Garforth Scott J.,Pirofski Liise-anne,Barnhill Jason,Applebaum Ariella,Fehn Karen,Krause Gregory J.,Fels J. Maximilian,Babb Rachelle,Daily Johanna P.,Yang Xiuyi A.,Quiroz Jose A.,Goldstein Doctor Y.,Gil Morayma Reyes,Allen Stephanie,Haslwanter Denise,Annam Jayabhargav,Yoon Hyun ah,Sample Reise,Thota Raja,Dieterle M. Eugenia,Serrano-Rahman Leana,Lally Brianna J.,Almo Steven C.,Laudermilch Ethan,Morano Nicholas C.,Ruiz Rafael,Nakouzi Antonio,Lee Max.Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC[EB/OL].(2025-03-28)[2025-04-27].https://www.medrxiv.org/content/10.1101/2020.12.02.20242909.点此复制
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