Revealing interspecies transmission barriers of avian influenza A viruses
Revealing interspecies transmission barriers of avian influenza A viruses
Abstract Influenza A virus (IAV) pandemics result from interspecies transmission events within the avian reservoir and further to mammals including humans. Investigating molecular virus–host interactions dictating this process and the adaptations to the new hosts that follow is vital to understand zoonotic IAV spread. Receptor incompatibility has been suggested to limit zoonotic IAV transmission from the wild bird reservoir. Other barriers to interspecies transmission, particularly within the avian system, largely remain elusive. Through assessment of infection dynamics of mallard origin IAV in two different avian hosts, coupled with studies of receptor expression and host response we aimed to reveal the host-pathogen interactions in a cross-species transmission event. We found that shedding patterns and innate immune responses were highly dependent on viral genotypes, host species and inoculation routes, but less dependent on receptor expression. Further, in contrary to the prevailing dogma we demonstrate that birds can produce a wide range of different sialylated structures also found in mammals, e.g. extended N- and O-linked Neu5Acα2,6 terminated glycans. Overall, receptor incompatibility is not the sole transmission barrier for IAV between birds and to humans, but other host-pathogen factors deserve dedicated studies to achieve proper pandemic preparedness.
Br?jer Caroline、Nilsson Jonas、Ellstr?m Patrik、Sihlbom Carina、Naguib Mahmoud M.、Lindskog Cecilia、Wille Michelle、Waldenstr?m Jonas、Larson G?ran、Jax Elinor、Kraus Robert H. S.、Lundkvist ?ke、Olsson Britt-Marie、Olsen Bj?rn、Eriksson Per、J?rhult Josef D.
Department of Pathology and Wildlife Diseases, National Veterinary Institute (SVA)Department of Laboratory Medicine, University of Gothenburg||Laboratory of Clinical Chemistry, Sahlgrenska University HospitalZoonosis Science Center, Department of Medical Sciences, Uppsala UniversityProteomics Core Facility, University of Gothenburg, Sahlgrenska AcademyZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala UniversityDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala UniversityZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala UniversityCentre for Ecology and Evolution in Microbial Model Systems, Linnaeus UniversityDepartment of Laboratory Medicine, University of Gothenburg||Laboratory of Clinical Chemistry, Sahlgrenska University HospitalDepartment of Migration, Max Planck Institute of Animal Behavior||Department of Biology, University of KonstanzDepartment of Migration, Max Planck Institute of Animal Behavior||Department of Biology, University of KonstanzZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala UniversityProteomics Core Facility, University of Gothenburg, Sahlgrenska AcademyZoonosis Science Center, Department of Medical Sciences, Uppsala UniversityZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala UniversityZoonosis Science Center, Department of Medical Sciences, Uppsala University
医学研究方法基础医学微生物学
Br?jer Caroline,Nilsson Jonas,Ellstr?m Patrik,Sihlbom Carina,Naguib Mahmoud M.,Lindskog Cecilia,Wille Michelle,Waldenstr?m Jonas,Larson G?ran,Jax Elinor,Kraus Robert H. S.,Lundkvist ?ke,Olsson Britt-Marie,Olsen Bj?rn,Eriksson Per,J?rhult Josef D..Revealing interspecies transmission barriers of avian influenza A viruses[EB/OL].(2025-03-28)[2025-08-29].https://www.biorxiv.org/content/10.1101/2020.11.17.386755.点此复制
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