The global distribution and spread of the mobilized colistin resistance gene mcr-1
The global distribution and spread of the mobilized colistin resistance gene mcr-1
Abstract Colistin represents one of the very few available drugs for treating infections caused by carbapenem resistant Enterobacteriaceae (CRE). As such, the recent plasmid-mediated spread of the mobilized colistin resistance gene mcr-1 poses a significant public health threat requiring global monitoring and surveillance. In this work, we characterize the global distribution of mcr-1 using a dataset of 457 mcr-1 positive sequenced isolates consisting of currently publicly available mcr-1 carrying sequences combined with an additional 110 newly sequenced mcr-1 positive isolates from China. We find mcr-1 in a diversity of plasmid backgrounds but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002-2008; 95% higher posterior density), followed by a dramatic demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of mobile elements carrying antibiotic resistance genes across multiple levels of genomic organization.
Wang Hui、Liu Yuqing、Bradley Phelim、van Dorp Lucy、Wang Qi、Wang Xiaojuan、Balloux Francois、Wang Ruobing、Jin Longyang、Zhang Qing、Iqbal Zamin、Didelot Xavier、Rieux Adrien、Dorai-Schneiders Thamarai、Weinert Lucy Anne、Shaw Liam
Department of Clinical Laboratory, Peking University People?ˉs HospitalInstitute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural SciencesWellcome Trust Centre for Human Genetics, University of OxfordUCL Genetics Institute, University College LondonDepartment of Clinical Laboratory, Peking University People?ˉs HospitalDepartment of Clinical Laboratory, Peking University People?ˉs HospitalUCL Genetics Institute, University College LondonDepartment of Clinical Laboratory, Peking University People?ˉs HospitalDepartment of Clinical Laboratory, Peking University People?ˉs HospitalInstitute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural SciencesEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome CampusDepartment of Infectious Disease Epidemiology, Imperial College LondonUMR PVBMT, CIRADDivision of Infection and Pathway MedicineDepartment of Veterinary MedicineUCL Genetics Institute, University College London
医药卫生理论药学微生物学
Wang Hui,Liu Yuqing,Bradley Phelim,van Dorp Lucy,Wang Qi,Wang Xiaojuan,Balloux Francois,Wang Ruobing,Jin Longyang,Zhang Qing,Iqbal Zamin,Didelot Xavier,Rieux Adrien,Dorai-Schneiders Thamarai,Weinert Lucy Anne,Shaw Liam.The global distribution and spread of the mobilized colistin resistance gene mcr-1[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/220921.点此复制
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