SARS-CoV-2 nucleocaspid antigen in urine of hospitalized patients with Covid-19
SARS-CoV-2 nucleocaspid antigen in urine of hospitalized patients with Covid-19
ABSTRACT SARS-CoV-2 nucleocapsid antigen (N-Ag) can be detected in the blood of patients with Covid-19. In this study, we used a highly sensitive and specific nucleocapsid-Ag assay to explore the presence of N-Ag in urine during the course of Covid-19, and explore its relationship with the severity of the disease in 82 hospitalized patients. High urinary N-Ag levels were associated with, admission in intensive care units, high C-reactive protein levels, lymphopenia, eosinopenia, high lactate dehydrogenase (LDH), and absence of SARS-CoV-2 nucleocapsid-IgG. Our study demonstrate that N-Ag is present in the urine of patients hospitalized in the early phase of Covid-19. As a direct marker of SARS-CoV-2, urinary N-Ag reflects the dissemination of viral compounds in the body. Urine N-Ag is a promising marker to predict adverse evolution of SARS-CoV-2 infections.
Debiess S、Bedin AS、Niel C、Tuaillon E、Van de Perre P、Pisoni A、Mondain AM、Le Moing V、Bollore K、Veyrenche N、Alcocer-Cordellat C、Makinson A
Pathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, EFS, University of AntillesPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, EFS, University of AntillesMontpellier University HospitalPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, EFS, University of AntillesPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, EFS, University of AntillesPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, EFS, University of AntillesMontpellier University HospitalTropical and Infectious Diseases, University Hospital INSERM U1175/IRD UMI 233, IRDPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, EFS, University of AntillesPathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, EFS, University of AntillesMontpellier University HospitalTropical and Infectious Diseases, University Hospital INSERM U1175/IRD UMI 233, IRD
医学研究方法基础医学临床医学
Debiess S,Bedin AS,Niel C,Tuaillon E,Van de Perre P,Pisoni A,Mondain AM,Le Moing V,Bollore K,Veyrenche N,Alcocer-Cordellat C,Makinson A.SARS-CoV-2 nucleocaspid antigen in urine of hospitalized patients with Covid-19[EB/OL].(2025-03-28)[2025-08-31].https://www.medrxiv.org/content/10.1101/2021.09.28.21264239.点此复制
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