SARS-CoV-2 Omicron VOC Transmission in Danish Households
SARS-CoV-2 Omicron VOC Transmission in Danish Households
1 Abstract The Omicron variant of concern (VOC) is a rapidly spreading variant of SARS-CoV-2 that is likely to overtake the previously dominant Delta VOC in many countries by the end of 2021. We estimated the transmission dynamics following the spread of Omicron VOC within Danish households during December 2021. We used data from Danish registers to estimate the household secondary attack rate (SAR). Among 11,937 households (2,225 with the Omicron VOC), we identified 6,397 secondary infections during a 1-7 day follow-up period. The SAR was 31% and 21% in households with the Omicron and Delta VOC, respectively. We found an increased transmission for unvaccinated individuals, and a reduced transmission for booster-vaccinated individuals, compared to fully vaccinated individuals. Comparing households infected with the Omicron to Delta VOC, we found an 1.17 (95%-CI: 0.99-1.38) times higher SAR for unvaccinated, 2.61 times (95%-CI: 2.34-2.90) higher for fully vaccinated and 3.66 (95%-CI: 2.65-5.05) times higher for booster-vaccinated individuals, demonstrating strong evidence of immune evasiveness of the Omicron VOC. Our findings confirm that the rapid spread of the Omicron VOC primarily can be ascribed to the immune evasiveness rather than an inherent increase in the basic transmissibility.
Mortensen Laust Hvas、Christiansen Lasse Engbo、Skov Robert Leo、Fomsgaard Anders、Nielsen Claus、Sieber Raphael Niklaus、Krause Tyra Grove、Kirkeby Carsten Thure、Rasmussen Morten、M?ller Camilla Holten、Spiess Katja、Stegger Marc、M?lbak K?re、Overvad Maria、Cohen Arieh Sierra、Denwood Matthew J.、M?ller Frederik Trier、Lyngse Frederik Plesner、Lassauni¨¨re Maria Magdalena
Statistics Denmark||Department of Public Health, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Applied Mathematics and Computer Science, Dynamical Systems, Technical University of DenmarkStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutDepartment of Bacteria, Parasites and Fungi, Statens Serum InstitutStatens Serum InstitutDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of CopenhagenStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutDepartment of Bacteria, Parasites and Fungi, Statens Serum InstitutStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of CopenhagenStatens Serum InstitutDepartment of Economics & Center for Economic Behaviour and Inequality, University of Copenhagen||Danish Ministry of Health||Statens Serum InstitutStatens Serum Institut
医学研究方法预防医学基础医学
Mortensen Laust Hvas,Christiansen Lasse Engbo,Skov Robert Leo,Fomsgaard Anders,Nielsen Claus,Sieber Raphael Niklaus,Krause Tyra Grove,Kirkeby Carsten Thure,Rasmussen Morten,M?ller Camilla Holten,Spiess Katja,Stegger Marc,M?lbak K?re,Overvad Maria,Cohen Arieh Sierra,Denwood Matthew J.,M?ller Frederik Trier,Lyngse Frederik Plesner,Lassauni¨¨re Maria Magdalena.SARS-CoV-2 Omicron VOC Transmission in Danish Households[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2021.12.27.21268278.点此复制
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