ORC2基因多态性与有氧耐力关联性研究

Objective: Determining whether single nucleotide polymorphisms (SNPs) in the TORC2 genes region contribute to endurance exercise capacity and searching for genetic marks associated for aerobic endurance performance. Methods: Rs6724,rs10908558 and rs10127983 in TORC2 gene regions were selected and the genotypes of the 123 cases and 127 controls were analyzed using the matrix assisted laser desorption ionisation-time of flight mass spectrometry method (MALDI-TOF).Results: frequency distribution of the 3 SNP is complete coincidence in control group. Allele frequency is 28.7%，71.3% and genotype frequency is 11.0%,35.4%,53.5%. There is no significant difference in the distribution of single location between case and control groups(P>0.05). The frequency of haplotype CC(rs6724 and rs10127983) was significantly higher in Marathon groups than controls(P=0.0035). Conclusion: Among the individual SNP examined，they are nearly completely disequilibrium．All those single polymorphism loci were individually not associated with aerobic endurance．It failed to be a genetic mark for aerobic endurance performance. Whether the haplotype CC in rs6742 and rs10127983 could be a genetic mark for Marthon need further research.