Inducible colistin resistance via a disrupted plasmid-borne mcr-1 gene in a 2008 Vietnamese Shigella sonnei isolate
Inducible colistin resistance via a disrupted plasmid-borne mcr-1 gene in a 2008 Vietnamese Shigella sonnei isolate
Abstract The mcr-1 gene, which confers resistance against the last-resort antimicrobial colistin, was recently discovered in Enterobacteriaceae circulating in China. Through genome sequencing we identified a plasmid-associated inactive form of mcr-1 in a 2008 Vietnamese isolate of Shigella sonnei. The plasmid was conjugated into E. coli and mcr-1 was activated upon exposure to colistin, suggesting the gene has been circulating in human-restricted pathogens for some time but carries a selective fitness cost.
The Hao Chung、Wick Ryan R.、Holt Kathryn E.、Thanh Duy Pham、Thi Nguyen To Nguen、Baker Stephen、Thwaites Guy、Tuyen Ha Thanh
The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research UnitCentre for Systems Genomics, The University of Melbourne||Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of MelbourneCentre for Systems Genomics, The University of Melbourne||Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of MelbourneThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research UnitThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research UnitThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit||Centre for Tropical Medicine and Global Health, Oxford University||The London School of Hygiene and Tropical MedicineThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit||Centre for Tropical Medicine and Global Health, Oxford UniversityThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
微生物学药学医学研究方法
The Hao Chung,Wick Ryan R.,Holt Kathryn E.,Thanh Duy Pham,Thi Nguyen To Nguen,Baker Stephen,Thwaites Guy,Tuyen Ha Thanh.Inducible colistin resistance via a disrupted plasmid-borne mcr-1 gene in a 2008 Vietnamese Shigella sonnei isolate[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/039925.点此复制
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