Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia
Cooley Gretchen 1Gwyn Sarah 2Pickering Harry 3Migchelsen Stephanie J 3Makalo Pateh 4Bailey Robin 3Martin Diana L 1Roberts Chrissy h 3Solomon Anthony W 3Joof Hassan 4Burr Sarah E. 5Mabey David CW 3Sep¨2lveda Nuno6
作者信息
- 1. Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention
- 2. IHRC, Inc., Centers for Disease Control and Prevention
- 3. Clinical Research Department, London School of Hygiene & Tropical Medicine
- 4. Disease Control and Elimination Theme, Medical Research Council
- 5. Clinical Research Department, London School of Hygiene & Tropical Medicine||Disease Control and Elimination Theme, Medical Research Council
- 6. Clinical Research Department, London School of Hygiene & Tropical Medicine||Centro de Estatistica e Aplica??es, Faculdade de Ci¨oncias, Universidade de Lisboa
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Abstract
ABSTRACT
Trachoma is caused by Chlamydia trachomatis (Ct). It is targeted for global elimination as a public health problem. In 2014, a population-based cross-sectional study was performed in two previously trachoma-endemic areas of The Gambia. Participants of all ages from Lower River Region (LRR) (N = 1028) and Upper River Region (URR) (N = 840) underwent examination for trachoma and had blood collected for detection of antibodies against the Ct antigen Pgp3, by ELISA. Overall, 30 (1.6%) individuals had active trachoma; the prevalence in children aged 1–9 years was 3.4% (25/742) with no statistically significant difference in prevalence between the regions. There was a significant difference in overall seroprevalence by region: 26.2% in LRR and 17.1% in URR (p<0.000l). In children 1–9 years old, seroprevalence was 4.4% in LRR and 3.9% in URR. Reversible catalytic models using information on age-specific seroprevalence demonstrated a decrease in the transmission of Ct infection in both regions, possibly reflecting the impact of improved access to water, health and sanitation as well as mass drug administration campaigns. Serological testing for antibodies to Ct antigens is potentially useful for trachoma programmes, but consideration should be given to the co-endemicity of sexually transmitted Ct infections.引用本文复制引用
Cooley Gretchen,Gwyn Sarah,Pickering Harry,Migchelsen Stephanie J,Makalo Pateh,Bailey Robin,Martin Diana L,Roberts Chrissy h,Solomon Anthony W,Joof Hassan,Burr Sarah E.,Mabey David CW,Sep¨2lveda Nuno.Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia[EB/OL].(2025-03-28)[2026-04-03].https://www.biorxiv.org/content/10.1101/149237.学科分类
眼科学/预防医学/医学研究方法
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