A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas
A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas
Abstract The mammalian visual system, from retina to neocortex, has been extensively studied at both anatomical and functional levels. Anatomy indicates the cortico-thalamic system is hierarchical, but characterization of cellular-level functional interactions across multiple levels of this hierarchy is lacking, partially due to the challenge of simultaneously recording activity across numerous regions. Here, we describe a large, open dataset (part of the Allen Brain Observatory) that surveys spiking from units in six cortical and two thalamic regions responding to a battery of visual stimuli. Using spike cross-correlation analysis, we find that inter-area functional connectivity mirrors the anatomical hierarchy from the Allen Mouse Brain Connectivity Atlas. Classical functional measures of hierarchy, including visual response latency, receptive field size, phase-locking to a drifting grating stimulus, and autocorrelation timescale are all correlated with the anatomical hierarchy. Moreover, recordings during a visual task support the behavioral relevance of hierarchical processing. Overall, this dataset and the hierarchy we describe provide a foundation for understanding coding and dynamics in the mouse cortico-thalamic visual system.
Ng Lydia、Bennett Corbett、Heller Greggory、Swapp Jackie、Gelfand Emily C.、Hancock Nicole、Harris Julie A.、Howard Robert、Iyer Ramakrishnan、Jessett Erika、Zeng Hongkui、Ledochowitsch Peter、Liang Elizabeth、Melchior Jose、Millman Daniel、Nayan Chelsea、North Kat、Oliver Michael、Perkins Jed、Reding Melissa、Reid David、Stoecklin Michelle、Sullivan David、Sutton Ben、Wakeman Wayne、Williams Derric、Choi Hannah、Arkhipov Anton、Brown Dillan、Buice Michael A.、Cho Andrew、Chvilicek Maggie、Dai Kael、Dietzman Roald、Nicovich Philip R.、Phillips John W.、Olsen Shawn R.、Koch Christof、Farrell Colin、Graddis Nile、Mollenkopf Tyler、Jia Xiaoxuan、Ngo Kiet、Robertson Miranda、Thompson Carol、Ronellenfitch Kara、Cain Nicolas、Lambert Sophie、Mihalas Stefan、Long Fuhui、Li Yang、Billeh Yazan N.、Garrett Marina、Slaughterbeck Cliff、Galbraith John、Denman Daniel J.、Kiggins Justin、Feng David、Luviano Jennifer A.、Esposito Luke、Pachitariu Marius、Mace Kyla、Reid R. Clay、Bernard Amy、Turner Kristen、Ramirez Tamina K.、Hytnen Ross、Lecoq Jerome、Ocker Gabriel Koch、Siegle Joshua H.、Caldejon Shiella、Leon Arielle、Hu Brian、de Vries Saskia E. J.、Cox Timothy C.、Williford Ali、Ahmed Ruweida、Johnson Katelyn、Kato India、Casal Linzy、Gale Sam、Groblewski Peter A.、Naylor Sarah、Seid Sam、Ollerenshaw Doug、Young Rob、Lee Jung Hoon、Durand S¨|verine、Nguyen Thuyahn、Whitesell Jennifer D.
Allen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain Science||University of Washington, Dept of Applied MathematicsAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain Science||The University of Colorado Denver, Anschutz Medical CampusAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceJanelia Research CampusAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceUniversity of Missouri-Kansas City School of DentistryAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain Science
生物科学理论、生物科学方法
Ng Lydia,Bennett Corbett,Heller Greggory,Swapp Jackie,Gelfand Emily C.,Hancock Nicole,Harris Julie A.,Howard Robert,Iyer Ramakrishnan,Jessett Erika,Zeng Hongkui,Ledochowitsch Peter,Liang Elizabeth,Melchior Jose,Millman Daniel,Nayan Chelsea,North Kat,Oliver Michael,Perkins Jed,Reding Melissa,Reid David,Stoecklin Michelle,Sullivan David,Sutton Ben,Wakeman Wayne,Williams Derric,Choi Hannah,Arkhipov Anton,Brown Dillan,Buice Michael A.,Cho Andrew,Chvilicek Maggie,Dai Kael,Dietzman Roald,Nicovich Philip R.,Phillips John W.,Olsen Shawn R.,Koch Christof,Farrell Colin,Graddis Nile,Mollenkopf Tyler,Jia Xiaoxuan,Ngo Kiet,Robertson Miranda,Thompson Carol,Ronellenfitch Kara,Cain Nicolas,Lambert Sophie,Mihalas Stefan,Long Fuhui,Li Yang,Billeh Yazan N.,Garrett Marina,Slaughterbeck Cliff,Galbraith John,Denman Daniel J.,Kiggins Justin,Feng David,Luviano Jennifer A.,Esposito Luke,Pachitariu Marius,Mace Kyla,Reid R. Clay,Bernard Amy,Turner Kristen,Ramirez Tamina K.,Hytnen Ross,Lecoq Jerome,Ocker Gabriel Koch,Siegle Joshua H.,Caldejon Shiella,Leon Arielle,Hu Brian,de Vries Saskia E. J.,Cox Timothy C.,Williford Ali,Ahmed Ruweida,Johnson Katelyn,Kato India,Casal Linzy,Gale Sam,Groblewski Peter A.,Naylor Sarah,Seid Sam,Ollerenshaw Doug,Young Rob,Lee Jung Hoon,Durand S¨|verine,Nguyen Thuyahn,Whitesell Jennifer D..A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas[EB/OL].(2025-03-28)[2025-06-14].https://www.biorxiv.org/content/10.1101/805010.点此复制
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