Functional consequences of pre- and postsynaptic expression of synaptic plasticity
Functional consequences of pre- and postsynaptic expression of synaptic plasticity
Abstract Experimental evidence has shown that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we discuss some of the functional consequences of this diversity in expression loci. In particular, using a biologically tuned model of spike-timing-dependent plasticity (STDP) we show that a combination of both pre- and postsynaptic components leads to 1) more reliable receptive fields, 2) rapid recovery of forgotten information, 3) and reduced response latencies, compared to a model with post-synaptic expression only. The diversity of expression of synaptic plasticity thus has important functional consequences. We propose that a considerable research effort is needed to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters network computations.
Costa Rui Ponte、van Rossum Mark C. W.、Mizusaki Beatriz E.P.、Sj?str?m P. Jesper
Institute for Adaptive and Neural Computation, School of Informatics University of Edinburgh||Centre for Neural Circuits and Behaviour University of OxfordInstitute for Adaptive and Neural Computation, School of Informatics University of EdinburghInstituto de F¨asica Universidade Federal do Rio Grande do Sul||Centre for Research in Neuroscience Department of Neurology and Neurosurgery Program for Brain Repair and Integrative Neuroscience The Research Institute of the McGill University Health Centre McGill UniversityCentre for Research in Neuroscience Department of Neurology and Neurosurgery Program for Brain Repair and Integrative Neuroscience The Research Institute of the McGill University Health Centre McGill University
生物科学理论、生物科学方法生物科学研究方法、生物科学研究技术
Costa Rui Ponte,van Rossum Mark C. W.,Mizusaki Beatriz E.P.,Sj?str?m P. Jesper.Functional consequences of pre- and postsynaptic expression of synaptic plasticity[EB/OL].(2025-03-28)[2025-05-22].https://www.biorxiv.org/content/10.1101/075317.点此复制
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