Myeloid-Derived Suppressor Cells are relevant factors to predict the severity of multiple sclerosis
Myeloid-Derived Suppressor Cells are relevant factors to predict the severity of multiple sclerosis
ABSTRACT Multiple Sclerosis (MS) is a highly heterogeneous demyelinating disease of the central nervous system (CNS) that needs for reliable biomarkers to foresee disease severity. Previous retrospective investigations in the MS model, experimental autoimmune encephalomyelitis (EAE), highlighted the important relationship between monocytic-myeloid-derived suppressor cells (M-MDSCs) and the experimented severity of the clinical course. In this work, we show for the first time cells resembling M-MDSCs associated to MS lesions, whose abundance was related to milder MS clinical courses. Moreover, Ly-6Chi cells (which are indistinguishable from circulating M-MDSCs in mice) are useful biomarkers to predict a milder severity of the EAE disease course and a lesser tissue damage extent. Finally, the abundance of M-MDSCs in blood from untreated MS patients at their first relapse was inversely correlated with EDSS at baseline and relapse recovery one-year later. In summary, our data point to M-MDSC load as a promising biomarker of patient’s clinical course severity. TeaserThe abundance of myeloid-derived suppressor cells is related to a milder clinical course in multiple sclerosis patients.
Fitzgerald Denise C.、Camacho-Toledano Celia、Mart¨anez-Gin¨|s Mar¨aa Luisa、Clemente Diego、Ortega Mar¨aa Cristina、Lebr¨?n-Gal¨￠n Rafael、Mach¨an-D¨aaz Isabel、Naughton Michelle、Garc¨aa-Arocha Jennifer、Goicoechea-Brice?o Haydee、Quintanero-Casero V¨actor、Garc¨aa-Montero Rosa、P¨|rez-Molina Inmaculada、Garc¨aa-Dom¨anguez Jose Manuel、Gal¨￠n Victoria、Vila-del Sol Virginia
Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen?ˉs University BelfastGrupo de Neuroinmuno-Reparaci¨?n, Hospital Nacional de Parapl¨|jicosDepartamento de Neurolog¨aa, Hospital General Universitario Gregorio Mara?¨?nGrupo de Neuroinmuno-Reparaci¨?n, Hospital Nacional de Parapl¨|jicosGrupo de Neuroinmuno-Reparaci¨?n, Hospital Nacional de Parapl¨|jicosGrupo de Neuroinmuno-Reparaci¨?n, Hospital Nacional de Parapl¨|jicosGrupo de Neuroinmuno-Reparaci¨?n, Hospital Nacional de Parapl¨|jicosWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen?ˉs University BelfastGrupo de Neuroinmuno-Reparaci¨?n, Hospital Nacional de Parapl¨|jicosDepartamento de Neurolog¨aa, Hospital General Universitario Gregorio Mara?¨?nGrupo de Neuroinmuno-Reparaci¨?n, Hospital Nacional de Parapl¨|jicosDepartamento de Neurolog¨aa, Hospital Universitario Virgen de la SaludDepartamento de Neurolog¨aa, Hospital Universitario Virgen de la SaludDepartamento de Neurolog¨aa, Hospital General Universitario Gregorio Mara?¨?nDepartamento de Neurolog¨aa, Hospital Universitario Virgen de la SaludServicio de Citometr¨aa de Flujo, Hospital Nacional de Parapl¨|jicos
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
Fitzgerald Denise C.,Camacho-Toledano Celia,Mart¨anez-Gin¨|s Mar¨aa Luisa,Clemente Diego,Ortega Mar¨aa Cristina,Lebr¨?n-Gal¨￠n Rafael,Mach¨an-D¨aaz Isabel,Naughton Michelle,Garc¨aa-Arocha Jennifer,Goicoechea-Brice?o Haydee,Quintanero-Casero V¨actor,Garc¨aa-Montero Rosa,P¨|rez-Molina Inmaculada,Garc¨aa-Dom¨anguez Jose Manuel,Gal¨￠n Victoria,Vila-del Sol Virginia.Myeloid-Derived Suppressor Cells are relevant factors to predict the severity of multiple sclerosis[EB/OL].(2025-03-28)[2025-06-23].https://www.biorxiv.org/content/10.1101/2022.04.20.488896.点此复制
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