Hippocampal Astrocytes Encode Reward Location
Hippocampal Astrocytes Encode Reward Location
Abstract Astrocytic calcium dynamics have been implicated in the encoding of sensory information, and modulating them has been shown to impact behavior. However, real-time calcium activity of astrocytes in the hippocampus of awake mice has never been investigated. We used 2-photon microscopy to chronically image CA1 astrocytes as mice ran in familiar or novel virtual environments and obtained water rewards. We found that astrocytes exhibit persistent ramping activity towards the reward location in a familiar environment, but not in a novel one. Using linear decoders, we could precisely predict the location of the mouse in a familiar environment from astrocyte activity alone. We could not do the same in the novel environment, suggesting astrocyte spatial activity is experience dependent. This is the first indication that astrocytes can encode location in spatial contexts, thereby extending their known computational capabilities, and their role in cognitive functions.
Benmelech-Chovav Aviya、Kreisel Tirzah、Doron Adi、Benaim Netai、Goshen Inbal、Carmi Tom、Rubin Alon、Ziv Yaniv
Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of JerusalemEdmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of JerusalemEdmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of JerusalemEdmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of JerusalemEdmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of JerusalemEdmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of JerusalemDepartment of Neurobiology, Weizmann Institute of ScienceDepartment of Neurobiology, Weizmann Institute of Science
细胞生物学生理学生物物理学
Benmelech-Chovav Aviya,Kreisel Tirzah,Doron Adi,Benaim Netai,Goshen Inbal,Carmi Tom,Rubin Alon,Ziv Yaniv.Hippocampal Astrocytes Encode Reward Location[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/2021.07.07.451434.点此复制
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