Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS
Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS
Loss of connectivity between spinal V1 inhibitory interneurons and motor neurons is found early in disease in the SOD1G93A ALS mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of the Extended Synaptotagmin 1 presynaptic organizer increases motor neuron survival and ameliorates motor phenotypes, demonstrating that interneurons can be a potential target to attenuate ALS symptoms.
Toft Sorensen Andreas、Stuckert Anna、Mora Santiago、von Huth Friis Rasmus、Selvan Raghavendra、Allodi Ilary、Noes-Holt Gith、Montanana-Rosell Roser
基础医学神经病学、精神病学分子生物学
Toft Sorensen Andreas,Stuckert Anna,Mora Santiago,von Huth Friis Rasmus,Selvan Raghavendra,Allodi Ilary,Noes-Holt Gith,Montanana-Rosell Roser.Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS[EB/OL].(2025-03-28)[2025-06-07].https://www.biorxiv.org/content/10.1101/2022.12.15.520568.点此复制
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