Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus
Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus
Abstract The 14th-18th century pandemic of Yersinia pestis caused devastating disease outbreaks in Europe for almost 400 years. The reasons for plague’s persistence and abrupt disappearance in Europe are poorly understood, but could have been due to either the presence of now-extinct plague foci in Europe itself, or successive disease introductions from other locations. Here we present five Y. pestis genomes from one of the last European outbreaks of plague, from 1722 in Marseille, France. The lineage identified has not been found in any extant Y. pestis foci sampled to date, and has its ancestry in strains obtained from victims of the 14th century Black Death. These data suggest the existence of a previously uncharacterized historical plague focus that persisted for at least three centuries. We propose that this disease source may have been responsible for the many resurgences of plague in Europe following the Black Death.
Herbig Alexander、Sahl Jason、Fourment Mathieu、Forrest Stephen A.、Schuenemann Verena J.、Golding Brian、Keim Paul、Wagner David M.、Krause Johannes、Poinar Hendrik N、Klunk Jennifer、Waglechner Nicholas、Kuch Melanie、Bos Kirsten I.、Poinar Debi、Holmes Edward C.、Dutour Olivier
Department of Archeological Sciences, University of Tuebingen||Max Planck Institute for the Science of Human HistoryCenter for Microbial Genetics and GenomicsMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical SchoolDepartment of Archeological Sciences, University of TuebingenDepartment of Archeological Sciences, University of TuebingenDepartment of Biology, McMaster UniversityCenter for Microbial Genetics and GenomicsCenter for Microbial Genetics and GenomicsDepartment of Archeological Sciences, University of Tuebingen||Max Planck Institute for the Science of Human HistoryMichael G. DeGroote Institute for Infectious Disease Research||McMaster Ancient DNA Centre, Department of Anthropology||Department of Biology, McMaster University||Department of Biochemistry, McMaster UniversityMcMaster Ancient DNA Centre, Department of Anthropology||Department of Biology, McMaster UniversityMichael G. DeGroote Institute for Infectious Disease ResearchMcMaster Ancient DNA Centre, Department of AnthropologyDepartment of Archeological Sciences, University of Tuebingen||Max Planck Institute for the Science of Human HistoryMcMaster Ancient DNA Centre, Department of AnthropologyMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical SchoolLaboratoire d?ˉanthropologie biologique Paul Broca
微生物学医学研究方法欧洲史
Herbig Alexander,Sahl Jason,Fourment Mathieu,Forrest Stephen A.,Schuenemann Verena J.,Golding Brian,Keim Paul,Wagner David M.,Krause Johannes,Poinar Hendrik N,Klunk Jennifer,Waglechner Nicholas,Kuch Melanie,Bos Kirsten I.,Poinar Debi,Holmes Edward C.,Dutour Olivier.Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus[EB/OL].(2025-03-28)[2025-05-14].https://www.biorxiv.org/content/10.1101/036509.点此复制
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