Assessing the influence of climate on future wintertime SARS-CoV-2 outbreaks

Abstract High susceptibility has limited the role of the climate in the SARS-CoV-2 pandemic to date. However, understanding a possible future effect of climate, as susceptibility declines and the northern-hemisphere winter approaches, is an important open question. Here we use an epidemiological model, constrained by observations, to assess the sensitivity of future SARS-CoV-2 disease trajectories to local climate conditions. We find this sensitivity depends on both the susceptibility of the population and the efficacy of non-pharmaceutical controls (NPIs) in reducing transmission. Assuming high susceptibility, more stringent NPIs may be required to minimize outbreak risk in the winter months. Our results imply a role for meteorological forecasts in projecting outbreak severity, however, reducing uncertainty in epidemiological parameters will likely have a greater impact on generating accurate predictions and reflects the strong leverage of NPIs on future outbreak severity.