Psychophysiologic symptom relief therapy (PSRT) for post-acute sequelae of COVID-19: a non-randomized interventional study
Psychophysiologic symptom relief therapy (PSRT) for post-acute sequelae of COVID-19: a non-randomized interventional study
Abstract ObjectiveTo determine if psychophysiologic symptom relief therapy (PSRT) will reduce symptom burden in patients suffering from post-acute sequelae of COVID-19 (PASC) who had mild/moderate acute COVID-19 disease without objective evidence of organ injury. Patients and MethodsTwenty-three adults under the age of 60 with PASC for at least 12 weeks following COVID-19 infection were enrolled in an interventional cohort study conducted via virtual platform between May 18, 2021 and August 7, 2022. Participants received PSRT during a 13 week (approximately 44 hour) course. Participants were administered validated questionnaires at baseline and at 4, 8, and 13 weeks. The primary outcome was change in somatic symptoms from baseline, measured using the Somatic Symptom Scale-8 (SSS-8). ResultsThe median duration of symptoms prior to joining the study was 267 days (IQR: 144, 460). The mean SSS-8 score of the cohort decreased from baseline by 8.5 (95% CI: 5.7-11.4), 9.4 (95% CI: 6.9-11.9), and 10.9 (95% CI: 8.3-13.5) at 4, 8, and 13 weeks respectively (all p<0.001). Participants also experienced statistically significant improvements across secondary outcomes including changes in dyspnea, fatigue, and pain (all p<0.001). ConclusionPSRT may effectively decrease symptom burden in patients suffering from PASC without evidence of organ injury. The study was registered on clinicaltrials.gov (NCT 04854772).
Silverman Jeremy、Cabrera Maria J、Balaji Lakshman、Tolin Rebecca、Grossestreuer Anne V、Donnino Michael、Edwards Robert、Berg Katherine M、Mehta Shivani、Howard Patricia、Yamin Jolin B
Department of Emergency Medicine, Beth Israel Deaconess Medical CenterDepartment of Emergency Medicine, Beth Israel Deaconess Medical CenterDepartment of Emergency Medicine, Beth Israel Deaconess Medical CenterRebecca Tolin, LLCDepartment of Emergency Medicine, Beth Israel Deaconess Medical CenterDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center||Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical CenterDepartment of Anesthesiology, Pain Management Center, Brigham and Women?ˉs Hospital, Harvard Medical SchoolDivision of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical CenterDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center||New York Institute of Technology College of Osteopathic MedicineDepartment of Emergency Medicine, Beth Israel Deaconess Medical CenterDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center
医学研究方法临床医学神经病学、精神病学
Silverman Jeremy,Cabrera Maria J,Balaji Lakshman,Tolin Rebecca,Grossestreuer Anne V,Donnino Michael,Edwards Robert,Berg Katherine M,Mehta Shivani,Howard Patricia,Yamin Jolin B.Psychophysiologic symptom relief therapy (PSRT) for post-acute sequelae of COVID-19: a non-randomized interventional study[EB/OL].(2025-03-28)[2025-05-08].https://www.medrxiv.org/content/10.1101/2022.10.07.22280732.点此复制
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