Age-Related Delay in Visual and Auditory Evoked Responses is Mediated by White and Gray matter Differences
Age-Related Delay in Visual and Auditory Evoked Responses is Mediated by White and Gray matter Differences
Abstract Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalographic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white- and gray-matter in a large (N=617, 18-88yrs), population-derived cohort (www.cam-can.org) to investigate the relationship between age-related structural differences and VEF and AEF delay across two different tasks. Using a novel technique, we show that VEFs exhibit a constant delay, whereas AEPs exhibit delay that accumulates over time. Visual delay is mediated by white-matter microstructure in the optic radiation, presumably reflecting increased transmission time, whereas auditory delay is mediated by gray-matter differences in auditory cortex, presumably reflecting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.
Taylor J. R.、CamCAN、Williams N.、Price D.、Neto Henriques R.、Campbell K.、Treder M.、Henson R. N. A.、Tyler L. K.
School of Psychological Sciences, University of ManchesterCambridge Centre for Ageing and Neuroscience, University of Cambridge and MRC Cognition and Brain Sciences UnitNeuroscience Centre, University of HelsinkiMedical Reasearch Council, Cognition and Brain Unit, CambridgeMedical Reasearch Council, Cognition and Brain Unit, CambridgeDepartment of Psychology, Brock UniversitySchool of Psychology, University of BirminghamMedical Reasearch Council, Cognition and Brain Unit, CambridgeCambridge Centre for Ageing and Neuroscience, University of Cambridge and MRC Cognition and Brain Sciences Unit
基础医学神经病学、精神病学生物科学研究方法、生物科学研究技术
Taylor J. R.,CamCAN,Williams N.,Price D.,Neto Henriques R.,Campbell K.,Treder M.,Henson R. N. A.,Tyler L. K..Age-Related Delay in Visual and Auditory Evoked Responses is Mediated by White and Gray matter Differences[EB/OL].(2025-03-28)[2025-05-12].https://www.biorxiv.org/content/10.1101/056440.点此复制
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