Not only a matter of age: Machine learning-based characterization of the differential effect of brain stimulation on skill acquisition
Not only a matter of age: Machine learning-based characterization of the differential effect of brain stimulation on skill acquisition
Abstract Brain stimulation shows potential at enhancing cognitive and motor functions in humans. However, multiple studies assessing its effects on behavior show heterogeneous results, especially in healthy older subjects. We propose a new method to predict an individual’s likelihood and the magnitude of the benefit from stimulation, based on the baseline performance of a sequential motor task, framed in the context of their age. Our results show a differential effect of stimulation, in which individuals with less efficient learning mechanisms benefit from stimulation, while those possessing optimal learning strategies resent a detrimental effect. Importantly, this differential effect was determined by one’s ability to integrate task-relevant information at the early stages of training, and not the age. This study paves the way towards the personalized application of stimulation to maximize its effects, and constitutes the first steps to implement an individualized translational clinical intervention, based on the state of the neural system. TeaserAge notwithstanding, brain stimulation is most effective in deficient neural systems, while being detrimental to optimal systems Visual abstractbiorxiv;2023.06.14.544579v1/UFIG1F1ufig1Main findingAnodal transcranial direct current stimulation (atDCS), applied over the hand representation of the motor cortex concomitant to the training of a sequential motor sequence, has differential effects as a function of the recipient’s ability to integrate task-relevant information at the early stages of training. Stimulation benefits individuals with seemingly less efficient learning mechanisms, enabling the rapid storage of the spatial coordinates of the motor sequence and an accelerated optimization of the accuracy of execution. In contrast, individuals possessing optimal learning mechanisms experience detrimental effects of stimulation, leading to drops in the accuracy of execution.
M¨1ller Henning、Schaer Roger、Hummel Friedhelm C.、Cohen Leonardo G.、Maceira-Elvira Pablo、Popa Traian、Cadic-Melchior And¨|ol、Schmid Anne-Christine
University of Applied Sciences Western Switzerland (HES-SO)University of Applied Sciences Western Switzerland (HES-SO)Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), ¨|cole Polytechnique F¨|d¨|rale de Lausanne (EPFL)||Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), EPFL Valais||Clinical Neuroscience, University of Geneva Medical SchoolHuman Cortical Physiology and Neurorehabilitation Section, NINDS, NIHDefitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), ¨|cole Polytechnique F¨|d¨|rale de Lausanne (EPFL)||Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), EPFL ValaisDefitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), ¨|cole Polytechnique F¨|d¨|rale de Lausanne (EPFL)||Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), EPFL ValaisDefitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), ¨|cole Polytechnique F¨|d¨|rale de Lausanne (EPFL)||Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), EPFL ValaisDefitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), ¨|cole Polytechnique F¨|d¨|rale de Lausanne (EPFL)||Defitech Chair for Clinical Neuroengineering, Neuro-X Institute (INX) and Brain Mind Institute (BMI), EPFL Valais
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
M¨1ller Henning,Schaer Roger,Hummel Friedhelm C.,Cohen Leonardo G.,Maceira-Elvira Pablo,Popa Traian,Cadic-Melchior And¨|ol,Schmid Anne-Christine.Not only a matter of age: Machine learning-based characterization of the differential effect of brain stimulation on skill acquisition[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/2023.06.14.544579.点此复制
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