Twinfilin1 controls lamellipodial protrusive activity and actin turnover during vertebrate gastrulation
Twinfilin1 controls lamellipodial protrusive activity and actin turnover during vertebrate gastrulation
Abstract The dynamic control of the actin cytoskeleton is a key aspect of essentially all animal cell movements. Experiments in single migrating cells and in vitro systems have provided an exceptionally deep understanding of actin dynamics. However, we still know relatively little of how these systems are tuned in cell-type specific ways, for example in the context of collective cell movements that sculpt the early embryo. Here, we provide an analysis of the actin severing and depolymerization machinery during vertebrate gastrulation, with a focus on Twinfilin1. We confirm previous results on the role of Twf1 in lamellipodia and extend those findings by linking Twf1, actin turnover, and cell polarization required for convergent extension during vertebrate gastrulation.
Papoulas Ophelia、Marcotte Edward M.、Lee Chanjae、Devitt Caitlin C.、Wallingford John B.、Cox Rachael M.、Alvarado Jos¨|
Department of Molecular Biosciences, University of TexasDepartment of Molecular Biosciences, University of TexasDepartment of Molecular Biosciences, University of TexasDepartment of Molecular Biosciences, University of TexasDepartment of Molecular Biosciences, University of TexasDepartment of Molecular Biosciences, University of TexasDepartment of Physics, University of Texas
细胞生物学分子生物学
Papoulas Ophelia,Marcotte Edward M.,Lee Chanjae,Devitt Caitlin C.,Wallingford John B.,Cox Rachael M.,Alvarado Jos¨|.Twinfilin1 controls lamellipodial protrusive activity and actin turnover during vertebrate gastrulation[EB/OL].(2025-03-28)[2025-06-15].https://www.biorxiv.org/content/10.1101/2020.09.03.281659.点此复制
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