Enhanced Contact Investigations for Nine Early Travel-Related Cases of SARS-CoV-2 in the United States
Haupt Thomas 1Marlow Mariel 2Jacobs Max W. 2Kim Moon 3Kita-Yarbro Amanda 4Novosad Shannon 2Patel Megan T. 5Robinson Susan 6Rolfes Melissa 2Klos Rachel 7Kobayashi Miwako 2Lang Misty 8Layden Jennifer 9Leidman Eva 2Lindstrom Stephen 2Spitters Chris 10Traub Elizabeth 3Fischer Marc 2Fisher Rebecca 3Foo Chelsea 3Freeman-Ponder Brandi 2Gant Jessica 8Clark Shauna 11Cody Sara 12Cohen Max 2Gunzenhauser Jeffrey 3Hall Aron J. 2Jarashow M. Claire 3Yousaf Anna 2Zahn Matthew 13Russell Denny 8Shetty Varun 14Burke Rachel M. 2Benowitz Isaac 2Biggs Holly M. 2Cates Jordan 14Chea Nora 2Wortham Jonathan 2Conners Erin E. 14Pillai Satish K. 2Barnes Emily 3Ibrahim Mireille B. 3Duchin Jeffrey 11Vahey Grace E. 14Grigg Cheri T. 2Beer Karlyn D. 2McPherson Tristan D. 15Dyal Jonathan W. 14Wallace Megan 14Westercamp Matthew 2Bartlett Karri 4Lindquist Scott 16Hunter Jennifer 2Bryant-Genevier Jonathan 14Fenstersheib Marty 17Pray Ian W. 18Donahue Matthew 14Kirking Hannah 2Xie Amy 2Scott Sarah 19McClung Nancy 2Pettrone Kristen 14Chatham-Stephens Kevin 20Bruce Hollianne 10Chu Victoria 14Reese Heather E. 14Ghinai Isaac 15DeSalvo Traci 1Rubin Rachel 21Christiansen Demian 22Joshi Kiran 22Sunenshine Rebecca 23Chiou Howard 24Feldstein Leora R. 2Mattison Claire P. 25Kocharian Anna 1Duca Lindsey 14Terashita Dawn 3Dratch Alissa 13Routh Janell 2Gounder Prabhu 26Stierman Bryan 14Fry Alicia M. 2Rhodes Heather 27Mello Lynn 28Rudman Sarah L. 29Barry Vaughn 14Han George S. 29Balter Sharon 3Kawakami Vance 11Dasari Vishal 2Link-Gelles Ruth 2Kamali Talar 3Gautom Romesh 16Verani Jennifer R. 2Smith-Jeffcoat Sarah E. 2Holshue Michelle 30Dawson Patrick 14Soda Elizabeth A. 2Midgley Claire M.2
作者信息
- 1. Wisconsin Department of Health Services
- 2. CDC COVID-19 Response Team
- 3. Los Angeles County Department of Public Health
- 4. Public Health Madison & Dane County
- 5. Illinois Department of Public Health
- 6. Arizona Department of Health Services
- 7. Wisconsin Division of Public Health
- 8. Washington State Public Health Lab
- 9. Chicago Department of Public Health
- 10. Snohomish Health District
- 11. Public Health Seattle-King County
- 12. County of Santa Clara, Public Health Department
- 13. Orange County Health Authority
- 14. CDC COVID-19 Response Team, Epidemic Intelligence Service
- 15. CDC COVID-19 Response Team, Chicago Department of Public Health, Epidemic Intelligence Service
- 16. Washington State Department of Health
- 17. San Benito County
- 18. CDC COVID-19 Response Team, Wisconsin Department of Health Services, Epidemic Intelligence Service
- 19. CDC COVID-19 Response Team, Maricopa County Department of Public Health, Epidemic Intelligence Service
- 20. FAAP, CDC COVID-19 Response Team
- 21. F.A.C.P., Cook County Department of Public Health
- 22. Cook County Department of Public Health
- 23. FIDSA, CDC COVID-19 Response Team, Maricopa County Public Health
- 24. CDC COVID-19 Response Team, Los Angeles County Public Health Department, CA, Epidemic Intelligence Service
- 25. CDC COVID-19 Response Team, Oak Ridge Institute for Science and Education
- 26. County of Los Angeles Public Health
- 27. CDC COVID-19 Response Team, Wyoming Department of Health, Epidemic Intelligence Service
- 28. San Benito County Public Health Services
- 29. County of Santa Clara Public Health Department
- 30. CDC COVID-19 Response Team, Washington Department of Health, Epidemic Intelligence Service
- 折叠
Abstract
ABSTRACT
BackgroundCoronavirus disease 2019 (COVID-19), the respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China and has since become pandemic. As part of initial response activities in the United States, enhanced contact investigations were conducted to enable early identification and isolation of additional cases and to learn more about risk factors for transmission.
MethodsClose contacts of nine early travel-related cases in the United States were identified. Close contacts meeting criteria for active monitoring were followed, and selected individuals were targeted for collection of additional exposure details and respiratory samples. Respiratory samples were tested for SARS-CoV-2 by real-time reverse transcription polymerase chain reaction (RT-PCR) at the Centers for Disease Control and Prevention.
ResultsThere were 404 close contacts who underwent active monitoring in the response jurisdictions; 338 had at least basic exposure data, of whom 159 had ≥1 set of respiratory samples collected and tested. Across all known close contacts under monitoring, two additional cases were identified; both secondary cases were in spouses of travel-associated case patients. The secondary attack rate among household members, all of whom had ≥1 respiratory sample tested, was 13% (95% CI: 4 – 38%).
ConclusionsThe enhanced contact tracing investigations undertaken around nine early travel-related cases of COVID-19 in the United States identified two cases of secondary transmission, both spouses. Rapid detection and isolation of the travel-associated case patients, enabled by public awareness of COVID-19 among travelers from China, may have mitigated transmission risk among close contacts of these cases.引用本文复制引用
Haupt Thomas,Marlow Mariel,Jacobs Max W.,Kim Moon,Kita-Yarbro Amanda,Novosad Shannon,Patel Megan T.,Robinson Susan,Rolfes Melissa,Klos Rachel,Kobayashi Miwako,Lang Misty,Layden Jennifer,Leidman Eva,Lindstrom Stephen,Spitters Chris,Traub Elizabeth,Fischer Marc,Fisher Rebecca,Foo Chelsea,Freeman-Ponder Brandi,Gant Jessica,Clark Shauna,Cody Sara,Cohen Max,Gunzenhauser Jeffrey,Hall Aron J.,Jarashow M. Claire,Yousaf Anna,Zahn Matthew,Russell Denny,Shetty Varun,Burke Rachel M.,Benowitz Isaac,Biggs Holly M.,Cates Jordan,Chea Nora,Wortham Jonathan,Conners Erin E.,Pillai Satish K.,Barnes Emily,Ibrahim Mireille B.,Duchin Jeffrey,Vahey Grace E.,Grigg Cheri T.,Beer Karlyn D.,McPherson Tristan D.,Dyal Jonathan W.,Wallace Megan,Westercamp Matthew,Bartlett Karri,Lindquist Scott,Hunter Jennifer,Bryant-Genevier Jonathan,Fenstersheib Marty,Pray Ian W.,Donahue Matthew,Kirking Hannah,Xie Amy,Scott Sarah,McClung Nancy,Pettrone Kristen,Chatham-Stephens Kevin,Bruce Hollianne,Chu Victoria,Reese Heather E.,Ghinai Isaac,DeSalvo Traci,Rubin Rachel,Christiansen Demian,Joshi Kiran,Sunenshine Rebecca,Chiou Howard,Feldstein Leora R.,Mattison Claire P.,Kocharian Anna,Duca Lindsey,Terashita Dawn,Dratch Alissa,Routh Janell,Gounder Prabhu,Stierman Bryan,Fry Alicia M.,Rhodes Heather,Mello Lynn,Rudman Sarah L.,Barry Vaughn,Han George S.,Balter Sharon,Kawakami Vance,Dasari Vishal,Link-Gelles Ruth,Kamali Talar,Gautom Romesh,Verani Jennifer R.,Smith-Jeffcoat Sarah E.,Holshue Michelle,Dawson Patrick,Soda Elizabeth A.,Midgley Claire M..Enhanced Contact Investigations for Nine Early Travel-Related Cases of SARS-CoV-2 in the United States[EB/OL].(2025-03-28)[2026-04-03].https://www.medrxiv.org/content/10.1101/2020.04.27.20081901.学科分类
预防医学/医学研究方法/医药卫生理论
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