Modeling brings additional insights into the kinetics of SARS-CoV-2 neutralizing antibody
Modeling brings additional insights into the kinetics of SARS-CoV-2 neutralizing antibody
Abstract Following the paper by Seow et al. published in Nature Microbiology, we reanalyzed the publicly available data using dynamical models of humoral response. The main conclusion is that, from available data, we can demonstrate that the decline of neutralizing antibodies (as measured with ID50) is biphasic, which is compatible with two types of antibody secreting cells (short lived and long lived). We found that lower bound of half life of the long-lived antibody secreting cells is 450 days. Moreover, our model predicts that the neutralizing antibody response could be more durable than suggested (up to 129 days for individuals with no requirement of supplemental oxygen and up to 175 days for others). A result which adds insight on the longevity of immune response.
Clairon Quentin、M¨|lanie Prague、Thi¨|baut Rodolphe、Guedj J¨|r¨|mie
University of Bordeaux, Inria Bordeaux Sud-Ouest, Inserm,Bordeaux Population Health Research Center, SISTM Team||Vaccine Research InstituteUniversity of Bordeaux, Inria Bordeaux Sud-Ouest, Inserm,Bordeaux Population Health Research Center, SISTM Team||Vaccine Research InstituteUniversity of Bordeaux, Inria Bordeaux Sud-Ouest, Inserm,Bordeaux Population Health Research Center, SISTM Team||Vaccine Research Institute||CHU BordeauxUniversit¨| de Paris, IAME, INSERM
医学研究方法基础医学生物科学研究方法、生物科学研究技术
Clairon Quentin,M¨|lanie Prague,Thi¨|baut Rodolphe,Guedj J¨|r¨|mie.Modeling brings additional insights into the kinetics of SARS-CoV-2 neutralizing antibody[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2021.10.13.21264693.点此复制
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