浙江嘉兴地区女性高危型人乳头瘤病毒亚型的分布情况及高危因素的分析

Objective To investigate the distribution of high-risk human papillomavirus (HR-HPV) subtypes and risk factors in local area, so as to provide reference for cervical cancer screening in high-risk population. Methods A total of 22573 women from Zhejiang Cervical Cancer screening project management system were selected for HR-HPV screening, and they were divided into HR-HPV positive group (2045 cases) and negative group (20528 cases). The medical history data of the patients were analyzed, and the risk factors of HR-HPV infection were analyzed by univariate and multivariate regression analysis. Results The overall HR-HPV infection rate was 9%. HPV52 was the most common type in single infection (29.6%), and HPV2 was the most common type in multiple infections (13%). There were significant differences between HR-HPV positive group and negative group in age, education level, gravidity, number of abortions and different neighborhoods (P < 0.05). Multivariate Logistic regression analysis showed that age >45 years old, primary school education or above, twice pregnancy were independent risk factors for HR-HPV infection. Conclusions: HPV52 is the predominant type of HR-HPV in the local area. Age >45 years, education level above primary school, and twice pregnancy are related risk factors for HR-HPV infection.