Towards multi-drug adaptive therapy
Towards multi-drug adaptive therapy
ABSTRACT A new ecologically inspired paradigm in cancer treatment known as “adaptive therapy” capitalizes on competitive interactions between drug-sensitive and drug-resistant subclones. The goal of adaptive therapy is to maintain a controllable stable tumor burden by allowing a significant population of treatment sensitive cells to survive. These, in turn, suppress proliferation of the less fit resistant populations. However, there remain several open challenges in designing adaptive therapies, particularly in extending these therapeutic concepts to multiple treatments. We present a cancer treatment case study (metastatic castrate resistant prostate cancer) as a point of departure to illustrate three novel concepts to aid the design of multi-drug adaptive therapies. First, frequency-dependent “cycles” of tumor evolution can trap tumor evolution in a periodic, controllable loop. Second, the availability and selection of treatments may limit the evolutionary “absorbing region” reachable by the tumor. Third, the velocity of evolution significantly influences the optimal timing of drug sequences.
West Jeffrey、Zhang Jingsong、Anderson Alexander R. A.、Brown Joel、Newton Paul K.、Gatenby Robert A.、You Li
Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research InstituteDepartment of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research InstituteIntegrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research InstituteIntegrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute||Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center & Research InstituteDepartment of Aerospace & Mechanical Engineering, Mathematics, and Norris Comprehensive Cancer Center, University of Southern CaliforniaIntegrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research InstituteDepartment of Data Science and Knowledge Engineering, Maastricht University
肿瘤学医学研究方法生物科学理论、生物科学方法
West Jeffrey,Zhang Jingsong,Anderson Alexander R. A.,Brown Joel,Newton Paul K.,Gatenby Robert A.,You Li.Towards multi-drug adaptive therapy[EB/OL].(2025-03-28)[2025-06-28].https://www.biorxiv.org/content/10.1101/476507.点此复制
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