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A Third Somatomotor Representation in the Human Cerebellum

A Third Somatomotor Representation in the Human Cerebellum

来源:bioRxiv_logobioRxiv
英文摘要

Seminal neurophysiological studies in the 1940s discovered two somatomotor maps in the cerebellum – an inverted anterior lobe map and an upright posterior lobe map. Both maps have been confirmed in the human using non-invasive neuroimaging with additional hints of a third map near to the cerebellar vermis. Here we sought direct evidence for the third somatomotor map by using intensive, repeated functional MRI (fMRI) scanning of individuals performing movements across multiple body parts (tongue, hands, glutes and feet). An initial discovery sample (N=4, 4 sessions per individual including 576 separate blocks of body movements) yielded evidence for the two established cerebellar somatomotor maps, as well as evidence for a third discontinuous foot representation near to the vermis. When the left versus right foot movements were directly contrasted, the third representation could be clearly distinguished from the second representation in multiple individuals. Functional connectivity from seed regions in the third somatomotor representation confirmed anatomically-specific connectivity with the cortex, paralleling the patterns observed for the two well-established maps. All results were prospectively replicated in an independent dataset with new individuals (N=4). These collective findings provide direct support for a third somatomotor map in the vermis of the cerebellum. We discuss the relations of this candidate third map to the broader topography of the cerebellum as well as its implications for understanding the specific organization of the human cerebellar vermis where distinct zones appear functionally specialized for somatomotor and visual domains.

Buckner Randy L.、DiNicola Lauren M.、Angeli Peter A.、Saadon-Grosman Noam

Department of Psychology, Center for Brain Science, Harvard University||Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital||Department of Psychiatry, Massachusetts General HospitalDepartment of Psychology, Center for Brain Science, Harvard UniversityDepartment of Psychology, Center for Brain Science, Harvard UniversityDepartment of Psychology, Center for Brain Science, Harvard University

10.1101/2022.04.13.488247

基础医学神经病学、精神病学生理学

Buckner Randy L.,DiNicola Lauren M.,Angeli Peter A.,Saadon-Grosman Noam.A Third Somatomotor Representation in the Human Cerebellum[EB/OL].(2025-03-28)[2025-08-03].https://www.biorxiv.org/content/10.1101/2022.04.13.488247.点此复制

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