Causality of Abdominal Obesity on Cognition: a Trans-ethnic Mendelian Randomization study
Causality of Abdominal Obesity on Cognition: a Trans-ethnic Mendelian Randomization study
Abstract Obesity has been associated with cognition in observational studies; however, whether its effect is confounding, reverse causality, or causal remains inconclusive. Using two-sample Mendelian randomization (MR) analyses, we investigated the causality of overall obesity, measured by BMI, and abdominal adiposity, measured by waist–hip ratio adjusted for BMI (WHRadjBMI), on cognition. Using summary data from the GIANT consortium, COGENT consortium, and UK Biobank of European ancestry, there was no causal effect of BMI on cognition performance (beta[95% CI]=-0.04[-0.12,0.04], p-value=0.35); however, a 1-SD increase in WHRadjBMI was associated with 0.07 standardized decrease in cognition performance (beta[95% CI]=-0.07[-0.12,-0.02], p=0.006). Using raw data from the Taiwan Biobank of Asian ancestry, there was no causal effect of BMI on cognitive aging (beta[95% CI]=0.00[-0.09,0.09], p-value=0.95); however, a 1-SD increase in WHRadjBMI was associated with a 0.17 standardized decrease in cognitive aging (beta[95% CI]=-0.17[-0.30,-0.03], p=0.02). This trans-ethnic MR study reveals that abdominal adiposity impairs cognition.
Lin Yen-Feng、Wu Chi-Shin、Chen Chia-Yen、Su Mei-Hsin、Hsiao Po-Chang、Feng Yen-Chen A.、Pan Yi-Jiun、Wang Shi-Heng
Center for Neuropsychiatric Research, National Health Research InstitutesNational Center for Geriatrics and Welfare Research, National Health Research Institutes||Department of Psychiatry, National Taiwan University HospitalBiogen||Stanley Center for Psychiatric Research, Broad Institute of MIT and HarvardDepartment of Occupational Safety and Health, College of Public Health, China Medical UniversityCollege of Public Health, National Taiwan UniversityCollege of Public Health, National Taiwan UniversitySchool of Medicine, College of Medicine, China Medical UniversityDepartment of Occupational Safety and Health, College of Public Health, China Medical University||Department of Public Health, College of Public Health, China Medical University
医学研究方法医药卫生理论神经病学、精神病学
Lin Yen-Feng,Wu Chi-Shin,Chen Chia-Yen,Su Mei-Hsin,Hsiao Po-Chang,Feng Yen-Chen A.,Pan Yi-Jiun,Wang Shi-Heng.Causality of Abdominal Obesity on Cognition: a Trans-ethnic Mendelian Randomization study[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2021.10.13.21264895.点此复制
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