中国北方地区汉族男性fTnT基因多态性与有氧耐力训练效果的关联研究
ssociation between fTnT gene polymorphism and aerobic endurance trainability of male han population in Northern China
目的：探讨中国北方平原地区汉族男性骨骼肌快肌肌钙蛋白T（fTnT）基因多态性与有氧耐力训练效果的关联性。方法：102名无训练史的健康男子进行18周的有氧耐力训练，测试其训练前后的最大摄氧量、跑节省化和无氧阈指标。采用应用聚合酶链反应和限制性片段长度多态性技术分析fTnT基因的T6835C和T17965C多态性。结果：（1）这两个多态位点分布频率均符合HW平衡。（2）T17965C多态性与rVOmax(ml/min/kg)的初始水平可能关联，TC基因型携带者rVO2max的初始水平显著高于CC基因型（p<0.05），且有高于TT的趋势（p＝0.09）。（3）未发现这两个多态位点与有氧耐力训练效果有关联。结论：fTnT基因的T6835C和T17965C多态性不是预测个体有氧耐力训练效果的基因标记。T6835C和T17965C多态性与有氧耐力表型指标初始水平不关联。
Objective: To explore the characteristics of polymorphism in the fTnT gene phenotypes and their response to the aerobic training. Methods: Ond hundred and two healthy men of Han nationality in northern China were recruited to undergo aerobic training program for 18 weeks. VO2max and RE and VT were measured on a tread-mill before and after the running program. The genotype were analyzed by PCR-RFLP. Results: (1)Genotype distributions were in Hardy-Weinberg equilibrium at all two loci. (2) A significant difference in across genotypes was observed at T17965C, and men carrying TC was at higher level than those carrying CC . (3)There was no sighificant association between phenotypes of VO2max、running economy(RE) and VT with the two loci polymorphisms. Therefore, it was suggested that the T6835C and T17965C were not gene markers for predicting trainability of endurance capacity and the two loci had no association with the baseline of representative indexes of aerobic endurance.
胡扬、席翼、文立、许春艳
遗传学生理学生物科学研究方法、生物科学研究技术
骨骼肌快肌肌钙蛋白T，基因多态性，有氧运动能力
fTnT，gene polymorphism aerobic capacity
胡扬,席翼,文立,许春艳.中国北方地区汉族男性fTnT基因多态性与有氧耐力训练效果的关联研究[EB/OL].(2006-08-08)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/200608-94.点此复制
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