The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland
The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland
Abstract BackgroundPatients with kidney failure requiring kidney replacement therapy (KRT) are at high risk of complications and death following SARS-CoV-2 infection with variable antibody responses to vaccination reported. We investigated the effects of COVID-19 vaccination on incidence of infection, hospitalization and death of COVID-19 infection. MethodsStudy design was an observational data linkage cohort study. Multiple healthcare datasets were linked to ascertain all SARS-CoV-2 testing, vaccination, hospitalization, and mortality data for all patients treated with KRT in Scotland, from the start of the pandemic over a period of 20 months. Descriptive statistics, survival analyses and vaccine effectiveness were calculated. ResultsAs of 19th September 2021, 93% (n=5281) of the established KRT population in Scotland had received two doses of an approved SARS-CoV-2 vaccine. Over the study period, there were 814 cases of SARS-CoV-2 infection (15.1% of the KRT population). Vaccine effectiveness against infection and hospitalization was 33% (95% CI 0-52) and 38% (95% CI 0-57) respectively. 9.2% of fully vaccinated individuals died within 28 days of a SARS-CoV-2 positive PCR test (7% dialysis patients and 10% kidney transplant recipients). This compares to <0.1% of the vaccinated Scottish population being admitted to hospital or dying death due to COVID19 during that period. ConclusionsThese data demonstrate a primary vaccine course of two doses has limited impact on COVID-19 infection and its complications in patients treated with KRT. Adjunctive strategies to reduce risk of both COVID-19 infection and its complications in this population are urgently required.
Traynor Jamie P、Mark Patrick B、Bell Samira、Almond Alison、Carr Edward J、Clark Laura、Joss Nicola、Petrie Michaela、Watters Chrissie、Spalding Elaine、Campbell Jacqueline、Sanu Vinod、Lambourg Emilie、Thomson Peter、O?ˉNeil Martin、Findlay Mark、Cousland Zoe、Buck Katharine、Metcalfe Wendy、Methven Shona
Glasgow Renal & Transplant Unit, Queen Elizabeth University HospitalGlasgow Renal & Transplant Unit, Queen Elizabeth University Hospital||Institute of Cardiovascular and Medical Sciences, University of GlasgowDivision of Population Health and Genomics, School of Medicine, University of Dundee||The Scottish Renal Registry, Scottish Health Audits, Public Health Scotland||Renal Unit, Ninewells HospitalRenal Unit, Mountainhall Treatment CentreCell Biology of Infection Laboratory, Francis Crick InstituteDepartment of Renal Medicine, Aberdeen Royal Infirmary, Foresterhill Health CampusRenal Unit, Raigmore HospitalDepartment of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh BioquarterThe Scottish Renal Registry, Scottish Health Audits, Public Health ScotlandRenal Unit, University Hospital CrosshousThe Scottish Renal Registry, Scottish Health Audits, Public Health ScotlandRenal Unit, Ninewells HospitalDivision of Population Health and Genomics, School of Medicine, University of DundeeGlasgow Renal & Transplant Unit, Queen Elizabeth University HospitalThe Scottish Renal Registry, Scottish Health Audits, Public Health ScotlandGlasgow Renal & Transplant Unit, Queen Elizabeth University HospitalRenal Unit, Monklands HospitalRenal Unit, Victoria HospitalDepartment of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh BioquarterDepartment of Renal Medicine, Aberdeen Royal Infirmary, Foresterhill Health Campus
预防医学临床医学内科学
Traynor Jamie P,Mark Patrick B,Bell Samira,Almond Alison,Carr Edward J,Clark Laura,Joss Nicola,Petrie Michaela,Watters Chrissie,Spalding Elaine,Campbell Jacqueline,Sanu Vinod,Lambourg Emilie,Thomson Peter,O?ˉNeil Martin,Findlay Mark,Cousland Zoe,Buck Katharine,Metcalfe Wendy,Methven Shona.The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2022.01.05.22268785.点此复制
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