Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts
Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts
SUMMARY BackgroundSuicidal behavior is highly heterogeneous and complex. A better understanding of its biological substrates and mechanisms could inform the design of more effective suicide prevention and intervention strategies. Neuroimaging studies of suicidality have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD working group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior. MethodsHere, we pool data from eighteen international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy controls and 6,448 people with depression, of whom 694 had attempted suicide). We compare regional cortical thickness and surface area, and measures of subcortical, lateral ventricular and intracranial volumes between suicide attempters, clinical controls (non-attempters with depression) and healthy controls. FindingsWe identified 25 regions of interest with statistically significant (FDR<0.05) differences between groups. Post-hoc examinations identified neuroimaging markers associated with suicide attempt over and above the effects of depression, including smaller volumes of the left and right thalamus and the right pallidum, and lower surface area of the left inferior parietal lobe. InterpretationThis study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt, and further demonstrates the need for well-powered samples and collaborative efforts to avoid reaching biased or misleading conclusions. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidality may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.
Dannlowski Udo、Wittfeld Katharina、Evans Jennifer W.、Erwin-Grabner Tracy、Davey Christopher G.、Grabe Hans J.、Grotegerd Dominik、Harrison Ben J.、Jahanshad Neda、Adams Mark J.、Baune Bernhard T.、Zarate Carlos A.、for the ENIGMA-MDD working group、Hatton Sean N.、Whalley Heather C.、Hickie Ian B.、Krug Axel、McMahon Katie、Medland Sarah E.、Meinert Susanne、Martin Nicholas G.、Opel Nils、Schrantee Anouk、Sim Kang、Singh Aditya、van der Wee Nic J.A.、Waltemate Lena、Schmitt Simon、Renter¨aa Miguel E.、Stein Frederike、Fu Cynthia H.Y.、Dima Danai、Ho Tiffany C.、Brosch Katharina、Reneman Liesbeth、Redlich Ronny、van Veltzen Laura S.、Meller Tina、Wright Margaret J.、McIntosh Andrew M.、Pozzi Elena、Veltman Dick J.、V?lzke Henry、Thompson Paul M.、Repple Jonathan、Harris Matthew A.、B¨1low Robin、Goya-Maldonado Roberto、Berger Klaus、Connolly Colm G.、Gotlib Ian H.、Campos Adrian I.、Nenadic Igor、Schmaal Lianne、Kircher Tilo、MacMaster Frank P.、Yang Tony T.、Hermesdorf Marco、Strike Lachlan T.、Lagopoulos Jim、Lemke Hannah、de Zubicaray Greig I.、Sacchet Matthew D.、van der Werff Steven J.A.
University of M¨1nster, Department of PsychiatryGerman Center for Neurodegenerative Disease, Site Rostock/Greifswald||Department of Psychiatry and Psychotherapy, University Medicine GreifswaldExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of HealthLaboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical CenterDepartment of Psychiatry, The University of Melbourne & Melbourne HealthGerman Center for Neurodegenerative Disease, Site Rostock/Greifswald||Department of Psychiatry and Psychotherapy, University Medicine GreifswaldUniversity of M¨1nster, Department of PsychiatryDepartment of Psychiatry, The University of Melbourne & Melbourne HealthImaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern CaliforniaDivision of Psychiatry, University of EdinburghUniversity of M¨1nster, Department of Psychiatry||Department of Psychiatry, The University of Melbourne||The Florey Institute of Neuroscience and Mental Health, The University of MelbourneExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of HealthBrain and Mind Centre, University of SydneyDivision of Psychiatry, University of EdinburghBrain and Mind Centre, University of SydneyPhilipps-University Marburg, Department of Psychiatry||Department of Psychiatry and Psychotherapy, University of BonnHerston Imaging Research Facility & School of Clinical Sciences, Queensland University of TechnologyFaculty of Medicine, The University of Queensland||Psychiatric Genetics Lab, QIMR Berghofer Medical Research Institute||School of Psychology, The University of QueenslandUniversity of M¨1nster, Department of PsychiatryGenetic Epidemiology Lab, QIMR Berghofer Medical Research InstituteUniversity of M¨1nster, Department of PsychiatryDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical CentersWest Region, Institute of Mental Health||Yong Loo Lin School of Medicine, National University of SingaporeLaboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical CenterDepartment of Psychiatry, Leiden University Medical Center||Leiden Institute for Brain and CognitionUniversity of M¨1nster, Department of PsychiatryPhilipps-University Marburg, Department of PsychiatryGenetic Epidemiology Lab, QIMR Berghofer Medical Research Institute||Faculty of Medicine, The University of QueenslandPhilipps-University Marburg, Department of PsychiatrySchool of Psychology, University of East London||Centre for Affective Disorders, Institute of Psychology, Psychiatry and Neuroscience, King?ˉs College LondonDepartment of Psychology, School of Arts and Social Sciences University of London||Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King?ˉs College LondonDepartment of Psychiatry & Weill Institute for Neurosciences, University of CaliforniaPhilipps-University Marburg, Department of PsychiatryDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical CentersUniversity of M¨1nster, Department of PsychiatryOrygen, The National Centre of Excellence in Youth Mental Health||Department of Psychiatry, The University of Melbourne & Melbourne HealthPhilipps-University Marburg, Department of PsychiatryQueensland Brain Institute, The University of Queensland||Centre for Advanced Imaging, The University of QueenslandDivision of Psychiatry, University of EdinburghOrygen, The National Centre of Excellence in Youth Mental Health||Department of Psychiatry, The University of Melbourne & Melbourne HealthAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & NeurosciencesInstitute for Community Medicine, University Medicine GreifswaldImaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern CaliforniaUniversity of M¨1nster, Department of PsychiatryDivision of Psychiatry, University of EdinburghInstitute of Diagnostic Radiology and Neuroradiology, University Medicine GreifswaldLaboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical CenterInstitute of Epidemiology and Social Medicine, University of M¨1nsterDepartment of Biomedical Sciences, Florida State UniversityDepartment of Psychology, Stanford UniversityGenetic Epidemiology Lab, QIMR Berghofer Medical Research Institute||Faculty of Medicine, The University of QueenslandPhilipps-University Marburg, Department of PsychiatryOrygen, The National Centre of Excellence in Youth Mental Health||Department of Psychiatry, The University of Melbourne & Melbourne HealthPhilipps-University Marburg, Department of PsychiatryDepartment of Pediatrics and Psychiatry, Cumming School of Medicine, University of Calgary||Strategic Clinical Network for Addictions and Mental Health, Alberta Health ServicesDepartment of Psychiatry & Weill Institute for Neurosciences, University of CaliforniaInstitute of Epidemiology and Social Medicine, University of M¨1nsterQueensland Brain Institute, The University of QueenslandBrain and Mind Centre, University of Sydney||Thompson Institute, University of the Sunshine CoastUniversity of M¨1nster, Department of PsychiatryInstitute of Health and Biomedical Innovation, Queensland University of TechnologyCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical SchoolDepartment of Psychiatry, Leiden University Medical Center||Leiden Institute for Brain and Cognition
神经病学、精神病学医学研究方法基础医学
Dannlowski Udo,Wittfeld Katharina,Evans Jennifer W.,Erwin-Grabner Tracy,Davey Christopher G.,Grabe Hans J.,Grotegerd Dominik,Harrison Ben J.,Jahanshad Neda,Adams Mark J.,Baune Bernhard T.,Zarate Carlos A.,for the ENIGMA-MDD working group,Hatton Sean N.,Whalley Heather C.,Hickie Ian B.,Krug Axel,McMahon Katie,Medland Sarah E.,Meinert Susanne,Martin Nicholas G.,Opel Nils,Schrantee Anouk,Sim Kang,Singh Aditya,van der Wee Nic J.A.,Waltemate Lena,Schmitt Simon,Renter¨aa Miguel E.,Stein Frederike,Fu Cynthia H.Y.,Dima Danai,Ho Tiffany C.,Brosch Katharina,Reneman Liesbeth,Redlich Ronny,van Veltzen Laura S.,Meller Tina,Wright Margaret J.,McIntosh Andrew M.,Pozzi Elena,Veltman Dick J.,V?lzke Henry,Thompson Paul M.,Repple Jonathan,Harris Matthew A.,B¨1low Robin,Goya-Maldonado Roberto,Berger Klaus,Connolly Colm G.,Gotlib Ian H.,Campos Adrian I.,Nenadic Igor,Schmaal Lianne,Kircher Tilo,MacMaster Frank P.,Yang Tony T.,Hermesdorf Marco,Strike Lachlan T.,Lagopoulos Jim,Lemke Hannah,de Zubicaray Greig I.,Sacchet Matthew D.,van der Werff Steven J.A..Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts[EB/OL].(2025-03-28)[2025-06-14].https://www.medrxiv.org/content/10.1101/2020.05.06.20090191.点此复制
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