Theory of mechano-chemical patterning in biphasic biological tissues
Theory of mechano-chemical patterning in biphasic biological tissues
The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a biologically realistic and unifying approach to emergent pattern formation. Our biphasic model of multicellular tissues incorporates turnover and transport of morphogens controlling cell differentiation and tissue mechanics in a single framework, where one tissue phase consists of a poroelastic network made of cells and the other is the extracellular fluid permeating between cells. While this model encompasses previous theories approximating tissues to inert monophasic media, such as Turing’s reaction-diffusion model, it overcomes some of their key limitations permitting pattern formation via any two-species biochemical kinetics thanks to mechanically induced cross-diffusion flows. Moreover, we unravel a qualitatively different advection-driven instability which allows for the formation of patterns with a single morphogen and which single mode pattern scales with tissue size. We discuss the potential relevance of these findings for tissue morphogenesis.
Recho Pierre、Hannezo Edouard、Hallou Adrien
LIPHY, CNRS UMR 5588 & Universit¨| Grenoble AlpesIST AustriaCavendish Laboratory, Department of Physics, University of Cambridge Wellcome Trust/CRUK Gurdon Institute, University of Cambridge Wellcome Trust/MRC Stem Cell Institute, University of Cambridge
生物物理学生物科学现状、生物科学发展
Recho Pierre,Hannezo Edouard,Hallou Adrien.Theory of mechano-chemical patterning in biphasic biological tissues[EB/OL].(2025-03-28)[2025-06-29].https://www.biorxiv.org/content/10.1101/484345.点此复制
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