Cross regional coordination of neural activity in the human brain during autobiographical self-referential processing
Cross regional coordination of neural activity in the human brain during autobiographical self-referential processing
SUMMARY For the human mind to operate, populations of neurons across remote regions of the brain need to coordinate their activity in the subsecond temporal scale. To date, our knowledge of such fast interactions involving cortical and subcortical structures in large brains, such as the human brain, remains limited. Here, we used stereo-electroencephalography (sEEG) recordings across four brain regions that are known, from decades of work, to be important for autobiographical memory processing. Our recordings involved 31 human participants implanted with intracranial electrodes in the hippocampus (HPC), posteromedial cortex (PMC), and ventromedial, as well as orbital subregions of the prefrontal cortex (OFC). In 14 subjects, we also recorded simultaneously in the anterior thalamus (ANT) across various experimental conditions and with direct electrical stimulations. Our observations provide new lines of correlative and causal evidence about the spatiotemporal profile of oscillatory coordination of cortical and subcortical activity during self-referential memory-based processing.
Parvizi Josef、Fang Ying、Wagner Anthony、Contreras Diego、Hugenard John、Buch Vivek、Stieger James R.、Perry Claire M.、Chen Qi、Lusk Zoe、Pinheiro-Chagas Pedro
Laboratory of Behavioral and Cognitive Neuroscience, Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine||Department of Neurology and Neurological Sciences, Stanford School of Medicine||Department of Neurosurgery, Stanford University, Stanford School of MedicineSchool of Psychology, South China Normal UniversityDepartment of Psychology, Stanford UniversityDepartment of Neuroscience, University of Pennsylvania School of MedicineDepartment of Neurology and Neurological Sciences, Stanford School of MedicineDepartment of Neurosurgery, Stanford University, Stanford School of MedicineLaboratory of Behavioral and Cognitive Neuroscience, Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine||Department of Neurology and Neurological Sciences, Stanford School of MedicineLaboratory of Behavioral and Cognitive Neuroscience, Human Intracranial Cognitive Electrophysiology Program, Stanford University School of MedicineSchool of Psychology, South China Normal UniversityLaboratory of Behavioral and Cognitive Neuroscience, Human Intracranial Cognitive Electrophysiology Program, Stanford University School of MedicineLaboratory of Behavioral and Cognitive Neuroscience, Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine
生理学生物物理学普通生物学
Parvizi Josef,Fang Ying,Wagner Anthony,Contreras Diego,Hugenard John,Buch Vivek,Stieger James R.,Perry Claire M.,Chen Qi,Lusk Zoe,Pinheiro-Chagas Pedro.Cross regional coordination of neural activity in the human brain during autobiographical self-referential processing[EB/OL].(2025-03-28)[2025-05-01].https://www.biorxiv.org/content/10.1101/2023.06.26.546582.点此复制
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