Spatial analysis for highly multiplexed imaging data to identify tissue microenvironments
Spatial analysis for highly multiplexed imaging data to identify tissue microenvironments
Abstract Highly multiplexed in situ imaging cytometry assays have made it possible to study the spatial organisation of numerous cell types simultaneously. We have addressed the challenge of quantifying complex multi-cellular relationships by proposing a statistical method which clusters local indicators of spatial association. Our approach successfully identifies distinct tissue architectures in datasets generated from three state-of-the-art high-parameter assays demonstrating its value in summarising the information-rich data generated from these technologies.
Sutherland Greg T.、Harman Andrew N.、Iyengar Sourish S.、Canete Nicolas P.、Yang Pengyi、Patrick Ellis
Charles Perkins Centre, The University of Sydney||School of Medical Sciences, Faculty of Medicine and Health, The University of SydneyCentre for Cancer Research, Westmead Institute for Medical Research, The University of Sydney||School of Medical Sciences, Faculty of Medicine and Health, The University of SydneySchool of Mathematics and Statistics, The University of SydneyCentre for Cancer Research, Westmead Institute for Medical Research, The University of Sydney||Sydney Medical School, Faculty of Medicine and Health, The University of SydneySchool of Mathematics and Statistics, The University of Sydney||Charles Perkins Centre, The University of Sydney||Computational Systems Biology Group, Children?ˉs Medical Research Institute, Faculty of Medicine and Health, The University of SydneySchool of Mathematics and Statistics, The University of Sydney||Centre for Cancer Research, Westmead Institute for Medical Research, The University of Sydney
生物科学研究方法、生物科学研究技术基础医学
Sutherland Greg T.,Harman Andrew N.,Iyengar Sourish S.,Canete Nicolas P.,Yang Pengyi,Patrick Ellis.Spatial analysis for highly multiplexed imaging data to identify tissue microenvironments[EB/OL].(2025-03-28)[2025-05-23].https://www.biorxiv.org/content/10.1101/2021.08.16.456469.点此复制
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