Human coronavirus reinfection dynamics: lessons for SARS-CoV-2
Human coronavirus reinfection dynamics: lessons for SARS-CoV-2
ABSTRACT In the current SARS-CoV-2 pandemic a key unsolved question is the quality and duration of acquired immunity in recovered individuals. This is crucial to solve, however SARS-CoV-2 has circulated for under five months, precluding a direct study. We therefore monitored 10 subjects over a time span of 35 years (1985-2020), providing a total of 2473 follow up person-months, and determined a) their antibody levels following infection by any of the four seasonal human coronaviruses, and b) the time period after which reinfections by the same virus can occur. An alarmingly short duration of protective immunity to coronaviruses was found by both analyses. We saw frequent reinfections at 12 months post-infection and substantial reduction in antibody levels as soon as 6 months post-infection. ONE SENTENCE SUMMARYCoronavirus protective immunity is short-lasting
Edridge Arthur W. D.、Bakker Margreet、Kinsella Cormac M.、Prins Maria、Sastre Patricia、van der Hoek Lia、Jebbink Maarten F.、Deijs Martin、Klein Michelle、Kaczorowska Joanna、Matser Amy、Hoste Alexis C. R.、Rueda Paloma
Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of AmsterdamLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of AmsterdamLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of AmsterdamDepartment of Infectious Diseases, Public Health Service of Amsterdam||Amsterdam UMC, University of Amsterdam, Department of Infectious Diseases, Amsterdam Infection & Immunity InstituteINGENASA, Inmunolog¨aa y Gen¨|tica Aplicada S. A., Av. de la Instituci¨?n Libre de Ense?anzaLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of AmsterdamLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of AmsterdamLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of AmsterdamLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of AmsterdamLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of AmsterdamDepartment of Infectious Diseases, Public Health Service of AmsterdamINGENASA, Inmunolog¨aa y Gen¨|tica Aplicada S. A., Av. de la Instituci¨?n Libre de Ense?anzaINGENASA, Inmunolog¨aa y Gen¨|tica Aplicada S. A., Av. de la Instituci¨?n Libre de Ense?anza
医药卫生理论医学研究方法基础医学
Edridge Arthur W. D.,Bakker Margreet,Kinsella Cormac M.,Prins Maria,Sastre Patricia,van der Hoek Lia,Jebbink Maarten F.,Deijs Martin,Klein Michelle,Kaczorowska Joanna,Matser Amy,Hoste Alexis C. R.,Rueda Paloma.Human coronavirus reinfection dynamics: lessons for SARS-CoV-2[EB/OL].(2025-03-28)[2025-06-18].https://www.medrxiv.org/content/10.1101/2020.05.11.20086439.点此复制
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