Autonomic and respiratory components of orienting behaviors are mediated by descending pathways originating from the superior colliculus
Autonomic and respiratory components of orienting behaviors are mediated by descending pathways originating from the superior colliculus
Summary The ability to discriminate competing, external stimuli, and initiate contextually appropriate behaviors, is a key brain function. Neurons in the deep superior colliculus (dSC) integrate multisensory inputs and activate descending projections to premotor pathways responsible for orienting and attention, behaviors which involve adjustments to respiratory and cardiovascular parameters. However, the neural pathways that subserve the physiological components of orienting are poorly understood. We report that orienting responses to optogenetic dSC stimulation are accompanied by short-latency autonomic, respiratory and electroencephalographic effects in awake rats, closely mimicking those evoked by naturalistic alerting stimuli. Physiological responses were not accompanied by detectable aversion or fear and persisted under urethane anesthesia, indicating independence from emotional stress. Moreover, autonomic responses were replicated by selective stimulation of dSC inputs to a subregion in the ventromedial medulla containing spinally-projecting premotor neurons. This putative disynaptic pathway from the dSC represents a likely substrate for autonomic components of orienting.
Monteiro Eloise、Burke Peter GR、Dempsey Bowen、Saleeba Christine、Allen Andrew M、Dampney Roger AL、Hildreth Cara M、Goodchild Ann K、Turner Anita、Lynch Erin、McMullan Simon、Cornish Jennifer L
Faculty of Medicine, Health & Human Sciences, Macquarie UniversityFaculty of Medicine, Health & Human Sciences, Macquarie UniversityInstitut de Biologie de l?ˉENS (IBENS), Inserm, CNRS, ¨|cole normale sup¨|rieure, PSL Research UniversityFaculty of Medicine, Health & Human Sciences, Macquarie UniversityDepartment of Anatomy and Physiology, University of MelbourneSchool of Medical Sciences (Physiology), University of SydneyFaculty of Medicine, Health & Human Sciences, Macquarie UniversityFaculty of Medicine, Health & Human Sciences, Macquarie UniversityFaculty of Medicine, Health & Human Sciences, Macquarie UniversityFaculty of Medicine, Health & Human Sciences, Macquarie UniversityFaculty of Medicine, Health & Human Sciences, Macquarie UniversityFaculty of Medicine, Health & Human Sciences, Macquarie University
生理学
Monteiro Eloise,Burke Peter GR,Dempsey Bowen,Saleeba Christine,Allen Andrew M,Dampney Roger AL,Hildreth Cara M,Goodchild Ann K,Turner Anita,Lynch Erin,McMullan Simon,Cornish Jennifer L.Autonomic and respiratory components of orienting behaviors are mediated by descending pathways originating from the superior colliculus[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/2021.06.10.447470.点此复制
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