cis-MoO2(BHAN)2 COMPLEX: ITS ROLE IN THE PROTECTION OF RADIATION-INDUCED DNA DAMAGE

The synthesized molybdenum complex, [cis-MoO2(BHAN)2] (BHAN= beta-hydroxy-alpha-naphthaldehyde), exhibits remarkable efficacy in safeguarding DNA against radiation-induced damage. Comparative studies reveal that the complex offers superior protection to radiolysed DNA compared to the ligand (BHAN). Notably, at a concentration of 2 mM, the complex demonstrates the capability to shield 90% of damaged plasmid DNA from a 20 Gy radiation exposure. Additionally, it also affords significant protection against radiation-induced damage to cellular DNA (CTDNA) from gamma rays. These findings underscore the significant potential of cis-MoO2(BHAN)2 as an effective radioprotector for normal tissues in the context of radiotherapy. The results of this study contribute valuable insights into the advancement of radioprotective strategies, presenting a noteworthy breakthrough with implications for future medical advancements.