首页|Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours
Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours
Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours
肿瘤学神经病学、精神病学医学研究方法
Oldridge Derek A.,Yang S.Y. Cindy,Bruce Jeffrey P.,Sorensen Poul H.,Sill Martin,Brabetz Sebastian,Jones David T.W.,Pfister Stefan M.,Raman Pichai,Resnick Adam C.,Sudhaman Sumedha,Lambo Sander,Pugh Trevor J.,Kool Marcel,Johann Pascal D.,Zhu Yuankun,Beck Pengbo,Zhu Kelsey,Nabbi Arash,Delaidelli Alberto,J?ger Natalie,Malkin David,Paulson Joseph N.,Mulder David T..Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours[EB/OL].(2025-03-28)[2025-10-25].https://www.biorxiv.org/content/10.1101/2022.09.20.508719.点此复制
To inform immunotherapy approaches in children, we performed an immunogenomic analysis of RNA-seq data from 925 treatment-naive pediatric nervous system tumours (pedNST) spanning 12 cancer types from three public data sets. Within pedNST, we uncovered four broad immune clusters: Pediatric Inflamed (10%), Myeloid Predominant (30%), Immune Neutral (43%) and Immune Excluded (17%). We validated these clusters using immunohistochemistry, methylation immune inference, and segmentation analysis of tissue images. We report shared biology of these immune clusters within and across cancer types, and characterization of specific immune-cell frequencies as well as T- and B-cell repertoires. We found no associations between immune infiltration levels and tumour mutational burden, although molecular cancer entities were enriched within specific immune clusters. Given the heterogeneity within pedNST, our findings suggest personalized immunogenomic profiling is needed to guide selection of immunotherapeutic strategies.
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